Results 101 to 110 of about 1,049,295 (319)

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The Plant Short-Chain Dehydrogenase (SDR) superfamily:genome-wide inventory and diversification patterns [PDF]

, 2012
Background Short-chain dehydrogenases/reductases (SDRs) form one of the largest and oldest NAD(P)(H) dependent oxidoreductase families. Despite a conserved 'Rossmann-fold' structure, members of the SDR superfamily exhibit low sequence similarities, which
Moummou, Hanane, Persson, B, van der Rest, Benoit,, Libert Brice Tonfack, Tonfack, LB, Tonfack, Libert Brice, Kallberg, Yvonne, Persson, Bengt, Bengt Persson, Kallberg, Y,, Benoît van der Rest, Moummou, Hanane,, Yvonne Kallberg, Brice Tonfack, Libert, Persson, Bengt,, Hanane Moummou, Van der Rest, Benoît, Kallberg, Yvonne,, Brice Tonfack, Libert,, van, der Rest B, Moummou, H   +20 more
core   +1 more source

The AP2/ERF Transcription Factor DRNL Modulates Gynoecium Development and Affects Its Response to Cytokinin

Frontiers in Plant Science, 2017
The gynoecium is the female reproductive system in flowering plants. It is a complex structure formed by different tissues, some that are essential for reproduction and others that facilitate the fertilization process and nurture and protect the ...
Yolanda Durán-Medina, Joanna Serwatowska, J. Irepan Reyes-Olalde, Stefan de Folter, Nayelli Marsch-Martínez   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

The multifunction of CLAVATA2 in plant development and immunity

Frontiers in Plant Science, 2016
The CLAVATA2 (CLV2) gene encodes a leucine-rich repeat (LRR) receptor-like protein (RLP), a class of cell surface receptors that lacks a cytoplasmic kinase domain.
Lixia Pan, Shuo Lv, Nan Yang, Yanting Lv, Zhijun Liu, Jinbin Wu, Guodong Wang   +6 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Plant basal resistance: genetics, biochemistry, and impacts on plant-biotic interactions

, 2012
Basal resistance depends largely on a diverse range of defence mechanisms that become active upon attack by pathogens or insects. These mechanisms range from rapid stomatal closure and production of reactive oxygen species, to callose deposition and ...
Ahmad, S., Sub Plant-Microbe Interactions, Plant Microbe Interactions   +2 more
core  

Prefoldin Subunits and Its Associate Partners: Conservations and Specificities in Plants

Plants
Prefoldins (PFDs) are ubiquitous co-chaperone proteins that originated in archaea during evolution and are present in all eukaryotes, including yeast, mammals, and plants.
Yi Yang, Gang Zhang, Mengyu Su, Qingbiao Shi, Qingshuai Chen   +4 more
doaj   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Dynamic Regulation and Function of Histone Monoubiquitination in Plants

Frontiers in Plant Science, 2014
Polyubiquitin chain deposition on a target protein frequently leads to proteasome-mediated degradation whereas monoubiquitination modifies target protein property and function independent of proteolysis. Histone monoubiquitination occurs in chromatin and
Jing eFeng, Wen Hui eShen
doaj   +1 more source