Results 111 to 120 of about 1,405,484 (345)

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Hop Crowning Trial [PDF]

open access: yes, 2016
Downy mildew has been identified as the primary pathogen plaguing our northeastern hop yards. This disease causes reduced yield, poor hop quality, and can cause the plant to die in severe cases.
Cubins, Julija   +3 more
core   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Heterogeneous microbial community associated with Bursaphelenchus xylophilus [PDF]

open access: yes, 2012
Pine wilt disease (PWD) is a complex disease integrating three major factors: the causal agent, the pinewood nematode Bursaphelenchus xylophilus; the insect-vector Monochamus spp.; and the host pine tree, Pinus sp.
Barbosa, Pedro   +6 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

Effect of extended egg quiescence and elevation in carbon dioxide on life history traits of Aedes aegypti

open access: yesScientific Reports
Elevation in carbon dioxide is a global threat, driving anthropogenic climate change. How disease-vectoring mosquitoes respond to these changes is currently largely unknown.
Sukritha Nalikkaramal   +2 more
doaj   +1 more source

Enhanced susceptibility of porcine muscle-derived mesenchymal stem cells to Aujeszky’s virus compared Vero cells

open access: yesAnimal Biotechnology
Mesenchymal stem cells (MSCs) can self-renew and differentiate into several lineages and can be isolated from different tissues such as bone marrow, adipose tissue, umbilical cord blood, and muscle.
Na-Yeon Gu   +6 more
doaj   +1 more source

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