Results 171 to 180 of about 1,276,626 (288)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Changes in plant diversity on the Qinghai-Tibet Plateau since the Anthropocene. [PDF]

Plant Divers
Sun H, Yang Y, Sun W, Li R, Deng T.
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Asynchrony and functional diversity couple herbivore community dynamics to host plant diversity. [PDF]

Nat Commun
Wang MQ, Albert G, Seifert CL, Chesters D, Bruelheide H, Li Y, Chen JT, Davrinche A, Haider S, Li S, von Oheimb G, Proß T, Ma K, Liu X, Luo A, Schuldt A, Zhu CD.   +16 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Plant diversity influences plant volatile emission with varying effects at the species and community levels. [PDF]

Proc Natl Acad Sci U S A
Medina-van Berkum P, Albracht C, Bröcher M, Solbach MD, Stein G, Bonkowski M, Buscot F, Heintz-Buschart A, Ebeling A, Eisenhauer N, El-Madany TS, Huang Y, Kuebler K, Meyer ST, Gershenzon J, Unsicker SB.   +15 more
europepmc   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Soil, competition, and niche shifts shape the floral mosaic of an annual plant diversity hotspot. [PDF]

Am J Bot
Fryer ER, O'Dell R, Grossenbacher DL, Shon A, McKinnon S, Rajakaruna N.   +5 more
europepmc   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Plant Diversity and Seasonal Variation Drive Animal Diversity and Community Structure in Eastern China. [PDF]

Animals (Basel)
Chen X, Jiang R, Chen Y, Yang R, He Y, Zou S, Ying J, Yi L, Ye Y, Peng S, Ge Z.   +10 more
europepmc   +1 more source