Results 41 to 50 of about 4,341,163 (257)

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Centromere organization and epigenetic regulation in Aristolochia fimbriata

Genome Biology
Background Aristolochia fimbriata (A. fimbriata), a magnoliid species similar to Amborella trichopoda, has not undergone additional whole genome duplications since the origin of extant flowering plants.
Kunpeng Li, Jie Li, Ran Zhao, Liuyu Qin, Yu Wang, Jieling Ren, Lei Ke, Jianyu Wang, Xin Yi, Yue Zhou, Yuannian Jiao   +10 more
doaj   +1 more source

Community-wide patterns in pollen and ovule production, their ratio (P/O), and other floral traits along an elevation gradient in southwestern China

BMC Plant Biology, 2023
Background As the male and female gametophytes of flowering plants, pollen and ovules largely determine the upper and lower boundaries of plant reproductive success.
Shristhi Nepal, Judith Trunschke, Zong-Xin Ren, Kevin S. Burgess, Hong Wang   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Integrated analysis of metabolome, transcriptome, and bioclimatic factors of Acer truncatum seeds reveals key candidate genes related to unsaturated fatty acid biosynthesis, and potentially optimal production area

BMC Plant Biology
Background Lipids found in plant seeds are essential for controlling seed dormancy, dispersal, and defenses against biotic and abiotic stress. Additionally, these lipids provide nutrition and energy and are therefore important to the human diet as edible
Yang Li, Fan Kong, Shangwei Wu, Wenjin Song, Yang Shao, Min Kang, Tiantian Chen, Liping Peng, Qingyan Shu   +8 more
doaj   +1 more source

A chromosome-scale assembly of the early-flowering Prunus campanulata and comparative genomics of cherries

Scientific Data, 2023
Prunus campanulata is an important flowering cherry germplasm of high ornamental value. Given its early-flowering phenotypes, P. campanulata could be used for molecular breeding of ornamental species and fruit crops belonging to the subgenus Cerasus ...
Yuxi Hu, Chao Feng, Baohuan Wu, Ming Kang   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Plant species or flower colour diversity? Identifying the drivers of public and invertebrate response to designed annual meadows [PDF]

, 2018
There is increasing evidence of the benefits of introducing urban meadows as an alternative to amenity mown grass in public greenspaces, both for biodiversity, and human wellbeing.
Norton, Briony, A., Norton, Briony, Russell, J.M., Hoyle, Helen, Hoyle, H., Russell, Jean M., Warren, Philip, Jean M. Russell, Warren, P., Briony Norton, Warren, Philip H., Norton, B., Philip Warren, Richards, J. Paul, Helen Hoyle, Dunnett, Nigel, Nigel Dunnett, Dunnett, N., Richards, J.P., J. Paul Richards   +19 more
core   +1 more source

Genome-wide survey indicates diverse physiological roles of the barley (Hordeum vulgare L.) calcium-dependent protein kinase genes

Scientific Reports, 2017
Calcium-dependent protein kinases (CDPKs) are crucial calcium sensors that play important roles in the regulation of plant growth and developmental processes, as well as protective responses to environmental stress. Here, we identified 28 CDPK genes from
Yunqiang Yang, Qiuli Wang, Qian Chen, Xin Yin, Min Qian, Xudong Sun, Yongping Yang   +6 more
doaj   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source