Results 101 to 110 of about 2,777,581 (246)

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Research progress on regulatory effects of plant extracts on meat quality of finishing pigs

Siliao yanjiu
Plant extracts are a general term for a category of bioactive substances obtained from natural plants through a series of processing and extraction methods.
JIA Weichao, YU Lihuai, DONG Li
doaj  

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Effect of plant extracts in controlling Sclerotinia sclerotiorum in French bean

, 2011
In vitro sensitivity of Sclerotinia sclerotiorum towards methanol extracts from 12 plant species namely Allamanda cathartica, Clerodendron infortunatum, Cactus species, Drymaria cordata, Mimosa pudica, Ocimum sanctum, Piper betle, Piper longum, Piper ...
Bhuyan, Deep Jyoti (R19430), Singh, L., Jha, D. K., Policegoudra, R. S., Chattapadhyay, P., Das, Jayshree   +5 more
core  

Isolation and structural confirmation of the oligosaccharides containing α-d-fructofuranoside linkages isolated from fermented beverage of plant extracts

, 2011
ArticleFermented beverage of plant extracts was prepared from the extracts of approximately 50 types of vegetables and fruits. Natural fermentation was carried out mainly by lactic acid bacteria (Leuconostoc spp.) and yeast (Zygosaccharomyces spp.
Fukushi, Eri, Onodera, Shuichi, Kawabata, Jun, Yamamori, Akira, 2845, 2844, 2843, Kawazoe, Naoki, 2842, 2841, Okada, Hideki, Shiomi, Norio, 2847, 2846   +13 more
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Efecto antimicrobiano de hojas de Melaleuca leucadendron L, que crece en la Ciénaga de Zapata Antimicrobial effect of the leaves of Melaleuca leucadendron L growing in Cienaga de Zapata

Revista Médica Electrónica, 2010
SUMARY Melaleuca leucadendron L is a tree commonly known as cayeput, being an invasive, undesirable species in Cienaga de Zapata, in the province of Matanzas. According to the referred usages, it might be exploited in a reasonable way as an antimicrobial
doaj  

Antibacterial and Antibiofilm Properties of Medicinal Plant Extracts against Multi Drug Resistant Staphylococcus Species and Non Fermenter Bacteria

, 2020
Antimicrobial resistance to the pathogenic microorganism has been characterized as a public health emergency both in the community and in hospitals. That is why; we need to find alternatives, which could be used as antibacterial agents.
Priya Mehrishi, Shobha Broor, Amisha Sharma, Priti Agarwal   +3 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source