Results 101 to 110 of about 10,639,356 (286)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Carbon isotope composition of boreal plants: functional grouping of life forms

Oecologia, 1997
 We tested the hypothesis that life forms (trees, shrubs, forbs, and mosses; deciduous or evergreen) can be used to group plants with similar physiological characteristics. Carbon isotope ratios (δ13C) and carbon isotope discrimination (Δ) were used as functional characteristics because δ13C and Δ integrate information about CO2 and water fluxes, and ...
Brooks, J.R., Flanagan, L.B., Buchmann, N., Ehlringer, J.R.   +3 more
openaire   +3 more sources

Species-specific traits plus stabilizing processes best explain coexistence in biodiverse fire-prone plant communities [PDF]

, 2013
Coexistence in fire-prone Mediterranean-type shrublands has been explored in the past using both neutral and niche-based models. However, distinct differences between plant functional types (PFTs), such as fire-killed vs resprouting responses to fire ...
Reineking Björn, Enright, N.J., Jürgen Groeneveld, Enright, Neal, Björn Reineking (113977), Byron B Lamont, Lamont, Byron, Reineking, B., Frank, K., Byron B. Lamont (296799), George L W Perry, Reineking, Bjorn, Neal J. Enright (296801), Karin Frank (211485), Groeneveld, Jurgen, Neal J Enright, Lamont Byron B., Jürgen Groeneveld (416288), George L. W. Perry (416289), Frank Karin, Groeneveld Jürgen, Perry, G.L.W., Perry, George, Lamont, B.B., Perry George L. W., Björn Reineking, Karin Frank, Perry, G., Enright Neal J., Groeneveld, J., Frank, Karin   +30 more
core   +1 more source

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Plant phenological sensitivity to climate change on the Tibetan Plateau and relative to other areas of the world

Ecosphere, 2019
Global warming and changes in precipitation are altering the phenology of plants that significantly impact the functioning and services of ecosystems.
Ji Suonan, Aimée T. Classen, Nathan J. Sanders, Jin‐Sheng He   +3 more
doaj   +1 more source

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

The influence of plant functional groups on ecosystem functions in a grassland in northern Canada

, 2010
Human development, climate change, diseases and habitat degradation and loss are resulting in species extinction rates up to a thousand times faster than pre‐human levels. Biodiversity ecosystem functioning research examines how this loss of species and changes in the composition of plant communities are likely to influence numerous ecosystem functions.
openaire   +1 more source

Just graze it! Biodiversity, nectar and forage resources in cultural landscapes grazed by different livestock species

Ecosystems and People
The Nordhordland UNESCO Biosphere Reserve encompasses a heterogeneous landscape which provides numerous ecosystem services. Semi-natural grasslands provide forage for traditionally managed livestock and are important sources of nectar and pollen for ...
Morgane Demeaux, Morgane Kerdoncuff, Amy Elizabeth Eycott, Inger Elisabeth Måren   +3 more
doaj   +1 more source

Functional group contributions to carbon fluxes in arctic-alpine ecosystems

Arctic, Antarctic, and Alpine Research, 2019
Ongoing responses to climate change in arctic-alpine ecosystems, including the increasing dominance of deciduous shrubs, involve major shifts in plant functional group composition.
G. Richard Strimbeck, Bente Jessen Graae, Simone Lang, Mia Vedel Sørensen   +3 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source