Results 171 to 180 of about 98,682 (291)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Carbon nanotube and carbon dot mediated plasmid DNA delivery in cowpea leaves. [PDF]

PLoS One
Saglam M, Tsakirpaloglou N, Bridgeland A, Miller R, Thomson MJ, Septiningsih EM.   +5 more
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Editorial: Transforming crop resilience with multi-omics approaches. [PDF]

Front Plant Sci
Nikolić A, Samardžić J, Božinović S.   +2 more
europepmc   +1 more source

GENETIC ENGINEERING STUDIES ON THE STRUCTURE AND FUNCTIONAL EXPRESSION OF CYTOCHROME P450 MONOOXYGENASES IN A HIGHER PLANT(高等動物におけるシトクロムP450モノオキシゲナーゼの構造と機能発現に関する遺伝子工学的研究)

, 1997
杉浦美羽
openalex   +1 more source

Genetically engineering Synechocystis sp. Pasteur Culture Collection 6803 for the sustainable production of the plant secondary metabolite p -coumaric acid [PDF]

, 2014
Yong Xue, Yan Zhang, Dan Cheng, Soumana Daddy, Qingfang He   +4 more
openalex   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Microbial strategies for drought stress mitigation- a sustainable frontier in plant resilience. [PDF]

Front Plant Sci
Gahlot KD.
europepmc   +1 more source

Genetic engineering and genome editing technologies as catalyst for Africa’s food security: the case of plant biotechnology in Nigeria [PDF]

Muyiwa S. Adegbaju, Titilayo Ajose, Ifeoluwa E Adegbaju, Temitayo Omosebi, Shakirat Oloruntoyin Ajenifujah‐Solebo, Olaitan Yetunde Falana, Olufunke Bolatito Shittu, Charles Oluwaseun Adetunji, Olalekan Akinbo   +8 more
openalex   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source