Results 111 to 120 of about 301,704 (359)

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Regulating sink-source ratio optimizes cotton defoliation efficiency during the early-to-mid flowering and boll stages

Industrial Crops and Products
The sink-source relationship significantly influences chemical defoliation in cotton. However, studies on the effects of sink-source manipulations at different phenological stages remain limited.
Zhenwang Zhang, Kexin Li, Jiaqi Zhang, Qinghua Liao, Yukun Wang, Xiaocheng Yuan, Keke Yu, Mingfeng Yang, Guodong Chen, Sumei Wan, Shanwei Lou, Fangjun Li, Mingwei Du, Xiaoli Tian, Zhaohu Li   +14 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Sink Strength Governs Yield Ceiling in High-Yield Cotton: Compensation Effects of Source–Sink Damage and Reproductive Stage Regulation

Agronomy
Under refined management, high-yield cotton fields are approaching their maximum output. However, how to break this yield upper limit, specifically the source–sink relationship is still inadequately researched.
Zhenwang Zhang, Kexin Li, Qinghua Liao, Zhijie Shi, Keke Yu, Junqi Zhu, Xiyu Jia, Guodong Chen, Sumei Wan, Shanwei Lou, Mingfeng Yang, Fangjun Li, Xiaoli Tian, Zhaohu Li, Mingwei Du   +14 more
doaj   +1 more source

Large-effect flowering time mutations reveal conditionally adaptive paths through fitness landscapes in Arabidopsis thaliana. [PDF]

, 2019
Contrary to previous assumptions that most mutations are deleterious, there is increasing evidence for persistence of large-effect mutations in natural populations.
Cooper, Martha D, Roe, Judith L, Runcie, Daniel E, Schmitt, Johanna, Taylor, Mark A, Welch, Stephen M, Wilczek, Amity M   +6 more
core  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

The fungicide pyraclostrobin affects gene expression by altering the DNA methylation pattern in Magnaporthe oryzae

Frontiers in Plant Science
IntroductionRice blast disease caused by Magnaporthe oryzae has long been the main cause of rice (Oryza sativa L.) yield reduction worldwide. The quinone external inhibitor pyraclostrobin is widely used as a fungicide to effectively control the spread of
Shumei Fang, Shumei Fang, Hanxin Wang, Kaihua Qiu, Yuanyuan Pang, Chen Li, Xilong Liang   +6 more
doaj   +1 more source

Perbanyakan Klonal Temu Mangga (Curcuma Mangga) Melalui Kultur in Vitro [PDF]

, 2003
Curcuma mangga is a medicinal crop species. This species has a good prospect for further development in conjunction with the back to nature concept in traditional medicine recently. C.
Hutami, S. (Sri), Purnamaningsih, R. (Ragapadmi)   +1 more
core  

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source