Results 51 to 60 of about 120,844 (263)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Characterizing Cotton Defoliation Progress via UAV-Based Multispectral-Derived Leaf Area Index and Analysis of Influencing Factors

Remote Sensing
Timely monitoring of cotton defoliation progress is crucial for optimizing the quality of mechanical harvesting. To accurately assess the defoliation status prior to mechanical picking, a field experiment was conducted in Hejian, Hebei Province, China ...
Yukun Wang, Zhenwang Zhang, Chenyu Xiao, Te Zhang, Keke Yu, Chong Zhang, Qinghua Liao, Fangjun Li, Sumei Wan, Guodong Chen, Xiaoli Tian, Mingwei Du, Zhaohu Li   +12 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Agronomic performance of sesame (Sesamum indicum L.) genotypes under phytostimulant application

Bioscience Journal, 2018
Sesame (Sesamum indicum L.) is one of the oldest cultivated plant species and become an important alternative to reduce food deficiency in low income populations.
Jeandson Silva Viana, Djayran Sobral Costa, Juliana Joice Pereira Lima, Edilma Pereira Gonçalves, Nair Helena Castro Arriel, José Fábio Ferreira de Oliveira   +5 more
doaj   +3 more sources

High nitrogen use efficiency in wheat is explained by a longer fast-increase period and adequate pre-anthesis nitrogen accumulation

Frontiers in Plant Science
IntroductionNitrogen (N)-efficient wheat cultivars achieve higher grain yields with equivalent N fertilizer inputs, and the grain filling character largely determines grain weight (GW) in cereal crops.
Minglong Yu, Churong Liu, Churong Liu, Hongrun Liu, Yushi Zhang, Zhaohu Li, Mingcai Zhang   +6 more
doaj   +1 more source

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Nitric Oxide Enhances Drought Tolerance in Gossypium hirsutum L. via S-Nitrosylation of the Plasma Membrane H⁺-ATPase Isoform GhHA2 and Antioxidant Defense Activation

Plants
(1) Background: Nitric oxide (NO) serves as a crucial signaling molecule in plant abiotic stress responses. Although its role in enhancing drought resistance in cotton has been recognized, the specific mechanisms underlying this physiological and ...
Yiping Sui, Shuying Li, Xiaoli Tian, Fangjun Li, Zhaohu Li   +4 more
doaj   +1 more source