Results 81 to 90 of about 149,239 (300)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

The Plant Short-Chain Dehydrogenase (SDR) superfamily:genome-wide inventory and diversification patterns [PDF]

, 2012
Background Short-chain dehydrogenases/reductases (SDRs) form one of the largest and oldest NAD(P)(H) dependent oxidoreductase families. Despite a conserved 'Rossmann-fold' structure, members of the SDR superfamily exhibit low sequence similarities, which
Moummou, Hanane, Persson, B, van der Rest, Benoit,, Libert Brice Tonfack, Tonfack, LB, Tonfack, Libert Brice, Kallberg, Yvonne, Persson, Bengt, Bengt Persson, Kallberg, Y,, Benoît van der Rest, Moummou, Hanane,, Yvonne Kallberg, Brice Tonfack, Libert, Persson, Bengt,, Hanane Moummou, Van der Rest, Benoît, Kallberg, Yvonne,, Brice Tonfack, Libert,, van, der Rest B, Moummou, H   +20 more
core   +1 more source

Field resistance to Orobanche crenata in pea (Pisum sativum L.): beyond strigolactones

BMC Plant Biology
Background Orobanchaceae are parasitic weeds causing substantial yield losses in many crops, including pea (Pisum sativum L.). Within host species, genotypes that display enhanced resistance to Orobanchaceae often exude low levels of strigolactones (SLs)
Francesco Arcieri, Gaetano Giudice, Marzia Guerriero, Chiara Delvento, Mario Schilder, Angelica Giancaspro, Pasquale Luca Curci, Catherine Rameau, Luigi Ricciardi, Concetta Lotti, Harro Bouwmeester, Imran Haider, Stefano Pavan   +12 more
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Flooding and low oxygen responses in plants [PDF]

, 2017
The world is currently experiencing dramatic increases in flood events impacting on natural vegetation and crops. Flooding often results in low O2 status in root tissues during waterlogging, but sometimes also in shoot tissues when plants become ...
Laurentius A. C. J. Voesenek, Plant Ecophysiology, Ole Pedersen, Pedersen, Ole, Voesenek, Laurentius A.C.J., Pierdomenico Perata, Voesenek, Laurentius A. C. J., Perata, Pierdomenico, Sub Plant Ecophysiology   +8 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

PIF4 and PIF4-Interacting Proteins: At the Nexus of Plant Light, Temperature and Hormone Signal Integrations

, 2021
Basic helix-loop-helix (bHLH) family transcription factor PHYTOCHROME INTERACTING FACTOR 4 (PIF4) is necessary for plant adaption to light or high ambient temperature.
Yang Xu, Ziqiang Zhu
core   +1 more source

In Vitro Multiplication, Antioxidant Activity, and Phytochemical Profiling of Wild and In Vitro-Cultured Plants of Kaempferia larsenii Sirirugsa—A Rare Plant Species in Thailand

Horticulturae
Kaempferia larsenii Sirirugsa, a rare species in Thailand belonging to the Zingiberaceae family, is known for its effective pharmaceutical properties.
Surapon Saensouk, Phiphat Sonthongphithak, Theeraphan Chumroenphat, Nooduan Muangsan, Phetlasy Souladeth, Piyaporn Saensouk   +5 more
doaj   +1 more source