Results 81 to 90 of about 230,888 (302)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Soil microbial legacy mediated by buckwheat flavonoids enhances cabbage resistance to clubroot disease

Microbiome
Background The legacy of plant growth significantly impacts the health of subsequent plants, yet the mechanisms by which soil legacies in crop rotation systems influence disease resistance through rhizosphere plant-microbiome interactions remain unclear.
Jiabing Wu, Shilin Hu, Jing Chen, Lili Zhou, Shengdie Yang, Na Zhou, Lei Wu, Guoqing Niu, Yong Zhang, Xuesong Ren, Qinfei Li, Jun Yuan, Hongyuan Song, Jun Si   +13 more
doaj   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Peptide Hormone‐Mediated Regulation of Plant Development and Environmental Adaptability

Advanced Science
Peptide hormones are essential signaling molecules in plants, playing critical roles in regulating growth and development, stress responses, and crop genetic improvement.
Xin Li, Liping Zhu, Huiqin Wang, Xin Zhou, Manhong Wang, Libei Li, Feng Liu, Jie Sun, Guanghui Xiao   +8 more
doaj   +1 more source

Abnormal flowers and pattern formation in floral [PDF]

, 1989
“From our acquaintance with this abnormal enabled to unveil the secrets that normal us, and to see distinctly what, from the regular we can only infer.” - J. W.
Bowman, John L., Meyerowitz, Elliot M., Smyth, David R.   +2 more
core  

Arabidopsis defense against Botrytis cinerea : chronology and regulation deciphered by high-resolution temporal transcriptomic analysis [PDF]

, 2012
Transcriptional reprogramming forms a major part of a plant’s response to pathogen infection. Many individual components and pathways operating during plant defense have been identified, but our knowledge of how these different components interact is ...
Atwell, Susanna, Baxter, Laura, Beynon, Jim, Borgwardt, Karsten M., Breeze, Emily, Buchanan-Wollaston, Vicky, Cooke, Emma J., Denby, Katherine J., Finkenstädt, Bärbel, Hickman, Richard J., Hill, Claire, Jenkins, Dafyd J., Kiddle, Steven J., Kim, Youn-sung, Kliebenstein, Daniel James, Legaie, Roxane, Madhou, Priyadharshini, McHattie, Stuart, Mead, A., Moore, Jonathan D., Ott, Sascha, Penfold, Christopher A., Rand, D. A., Rhodes, Johanna, Stegle, Oliver, Tabrett, Alex, Wild, David L., Windram, Oliver P., Zhang, Cunjin   +28 more
core   +3 more sources

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Simultaneous determination of five plant hormones in cotton leaves using QuEChERS combined with HPLC‒MS/MS

Journal of Cotton Research
Background Plant hormones profoundly influence cotton growth, development, and responses to various stresses. Therefore, there is a pressing need for an efficient assay to quantify these hormones in cotton.
Wenhao Wang, Xianpeng Song, Dan Wang, Yajie Ma, Yongpan Shan, Xiangliang Ren, Hongyan Hu, Changcai Wu, Jun Yang, Yan Ma   +9 more
doaj   +1 more source