Results 221 to 230 of about 18,810 (305)

Immunosenescence Profile Is Associated With Increased Susceptibility to Severe COVID‐19

Aging Cell, EarlyView.
(A) A previous immunosenescence profile in individuals infected with SARS‐CoV2 creates a permissive environment for progression to severe COVID‐19: higher inflammaging, accumulation of exhausted/senescent T cells, an oligoclonal B‐cell repertoire, and accelerated epigenetic age.
Lucas Haniel A. Ventura, Lícia Torres, Giovanna Caliman Camatta, Jofer Zamame, Monique Macedo Coelho, Cecília Horta Ramalho‐Pinto, João Gervazio, Felipe Caixeta, Leandro Nascimento, Mariana Almeida Oliveira, Vinícius Dantas Martins, Marcos Felipe Oliveira, Murilo Soares Costa, Hugo Itaru Sato, Henrique Cerqueira Guimarães, Rafael Calvão Barbuto, Ana Paula Rocha Veiga, Najara Ataíde, Gabriela Prandi Caetano, Sarah Rangon, Mauro Lúcio O. Júnior, Fernanda Calvo Fortes, Luciana Zuccherato, Elaine Speziali, Olindo Assis Martins‐Filho, Verônica Coelho, Roberto Avritchir, Rafael Souza, Marina Ayupe, Caio Loureiro, Maria Eduarda Passos, Ana Clara Mota Neves, Pauline Leite, Santuza Maria Ribeiro Teixeira, Unaí Tupinambás, Liza Figueiredo Felicori, Gabriela Silveira‐Nunes, Tatiani Uceli Maioli, Denise Morais Fonseca, Andrea Teixeira‐Carvalho, Ana Maria Caetano Faria   +40 more
wiley   +1 more source

Soybean Lectin Cross-Links Membranes by Binding Sulfatide in a Curvature-Dependent Manner. [PDF]

J Agric Food Chem
Okedigba AO, Ng EL, Deegbey M, Rosso ML, Ngo W, Xiao R, Huang H, Zhang B, Vaissier Welborn V, Capelluto DGS.   +9 more
europepmc   +1 more source

Age and Sex Effects on Blood Retrotransposable Element Expression Levels: Findings From the Population‐Based Rhineland Study

Aging Cell, EarlyView.
Retrotransposable element (RTE) expression increases with chronological and biological age and is negatively associated with heterochromatin regulators. Moreover, RTE expression shows sex‐specific differences, with higher levels in men and enrichment for immune‐related pathways.
Valentina Talevi, Hang‐Mao Lee, Dan Liu, Marc D. Beyer, Paolo Salomoni, Monique M. B. Breteler, N. Ahmad Aziz   +6 more
wiley   +1 more source

Novel Lectins from <i>Bauhinia</i> with Differential <i>N-</i>Glycan Binding Profiles. [PDF]

ACS Omega
Osterne VJS, Lima LD, Oliveira MV, Pinto-Junior VR, Neto CC, Correia SEG, Suarez C, Van Damme EJM, Serna S, Reichardt NC, Nascimento KS, Cavada BS.   +11 more
europepmc   +1 more source

Aging Compromises Terminal Differentiation Program of Cytotoxic Effector Lineage and Promotes Exhaustion in CD8+ T Cells Responding to Coronavirus Infection

Aging Cell, EarlyView.
In a MHV infection model with age‐associated increased mortality, we demonstrate that aging impairs, instead of promoting, the terminal differentiation program of virus‐specific CD8+ T cells through downregulating key transcriptional regulators of terminal differentiation.
Ziang Zhu, Guohua Lou, Ying Luo, Kiddist Yihunie, Jonathan Hoar, Juan A. Daniel, Bret M. Evers, Chen Yao, Tuoqi Wu   +8 more
wiley   +1 more source

The Promising Role of Plant-Derived Lectins in Oral Cancer Therapeutics: A Systematic Review. [PDF]

Cureus
Ramsridhar S, Rajkumar C, Balasubramaniam M, Anandan S, Sabesan M, Jayamani L.   +5 more
europepmc   +1 more source

Targeting CA2 Perineuronal Nets Restores Recognition Memory and Theta Oscillations in Aged Mice

Aging Cell, EarlyView.
Targeting CA2 perineuronal nets restores social/non‐social recognition memory and theta oscillations in aged mice: Aged mice displayed deficits in both social and object recognition memory, which were accompanied by enhanced perineuronal nets (PNNs) density and reduced theta power in the dCA2 region.
Sonam Fathima Mehak, Apoorva Bettagere Shivakumar, Feyba Jijimon, Amritanshu Gupta, Vikram Gopalakrishna Pillai, Gireesh Gangadharan   +5 more
wiley   +1 more source

Ethnobotanical Use, Phytochemistry, Pharmacology, and Toxicity of <i>Canavalia gladiata</i>. [PDF]

Drug Des Devel Ther
Qian H, Meng D, Yue L, Xu H, Feng K, Wang J.   +5 more
europepmc   +1 more source

Gastrointestinal Barrier Disruption in Post‐COVID Syndrome Fatigue Patients

Allergy, EarlyView.
Gastrointestinal (GI) barrier disruption in the context of SARS‐CoV‐2 infection is associated with the development of Post‐COVID Syndrome (PCS) Fatigue. Pre‐existing GI complaints may predispose to fatigue development. Monitoring GI symptoms and markers before, during, and after SARS‐CoV‐2 infection is crucial for identifying predictive clinical ...
Johanna Rohrhofer, Viktoria Wolflehner, Johannes Schweighardt, Larissa Koidl, Michael Stingl, Sonja Zehetmayer, Joana Séneca, Petra Pjevac, Eva Untersmayr   +8 more
wiley   +1 more source

<i>Vatairea</i> Genus as a Potential Therapeutic Agent-A Comprehensive Review of Ethnobotanical, Phytochemical, and Pharmacological Properties. [PDF]

Pharmaceuticals (Basel)
Toledo SA, Reis LDDS, da Conceição BC, Pantoja LVPDS, de Souza-Junior FJC, Garcez FCS, Maia CSF, Fontes-Junior EA.   +7 more
europepmc   +1 more source