Results 121 to 130 of about 533,838 (264)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

∆8-THC, THC-O Acetates and CBD-di-O Acetate: Emerging Synthetic Cannabinoids Found in Commercially Sold Plant Material and Gummy Edibles. [PDF]

J Anal Toxicol, 2022
Holt AK, Poklis JL, Peace MR.
europepmc   +1 more source

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Integrated Membrane Filtration for the Recovery of Antioxidants from Lavender Spent Plant Material. [PDF]

Membranes (Basel)
Stoyanova Y, Lazarova-Zdravkova N, Pietsch-Braune S, Petrin S, Stefanova A, Heinrich S, Peshev D.   +6 more
europepmc   +1 more source

Supercritical carbon dioxide decellularization of plant material to generate 3D biocompatible scaffolds. [PDF]

Sci Rep, 2021
Harris AF, Lacombe J, Liyanage S, Han MY, Wallace E, Karsunky S, Abidi N, Zenhausern F.   +7 more
europepmc   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Acinetobacter baumannii's lifestyle includes soil-dwelling colonization of decaying plant material and airborne spread. [PDF]

Nat Commun
Wilharm G, Skiebe E, Michalska A, Higgins PG, Weber K, Schaudinn C, Neugebauer C, Görlitz K, Meimers G, Rizova Y, Blaschke U, Heider C, Cuny C, Drewes S, Heuser E, Jeske K, Jacob J, Ulrich RG, Bocheński M, Kasprzak M, Burda E, Ciepliński M, Kaługa I, Jankowiak Ł, Aguirre JI, López-García A, Höfle U, Jagiello Z, Tobółka M, Janic B, Zieliński P, Kamiński M, Frisch J, Siekiera J, Wendel AF, Brauner P, Jäckel U, Kaatz M, Müller S, Lübke-Becker A, Wieler LH, von Wachsmann J, Thrukonda L, Helal M, Epping L, Wolf SA, Semmler T, Jerzak L.   +47 more
europepmc   +1 more source

Plant Material as a Novel Tool in Designing and Formulating Modern Biostimulants-Analysis of Botanical Extract from Linum usitatissimum L. [PDF]

Materials (Basel), 2021
Kocira S, Szparaga A, Krawczuk A, Bartoš P, Zaguła G, Plawgo M, Černý P.   +6 more
europepmc   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

Comparison of Different Methods of Molecular Detection of Erwinia amylovora in Plant Material. [PDF]

Curr Issues Mol Biol
Pozharskiy A, Kostyukova V, Nizamdinova G, Gritsenko D.   +3 more
europepmc   +1 more source