Results 141 to 150 of about 8,307,299 (283)

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Integrated Membrane Filtration for the Recovery of Antioxidants from Lavender Spent Plant Material. [PDF]

Membranes (Basel)
Stoyanova Y, Lazarova-Zdravkova N, Pietsch-Braune S, Petrin S, Stefanova A, Heinrich S, Peshev D.   +6 more
europepmc   +1 more source

Supercritical carbon dioxide decellularization of plant material to generate 3D biocompatible scaffolds. [PDF]

Sci Rep, 2021
Harris AF, Lacombe J, Liyanage S, Han MY, Han MY, Wallace E, Karsunky S, Abidi N, Zenhausern F.   +8 more
europepmc   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Acinetobacter baumannii's lifestyle includes soil-dwelling colonization of decaying plant material and airborne spread. [PDF]

Nat Commun
Wilharm G, Skiebe E, Michalska A, Higgins PG, Weber K, Schaudinn C, Neugebauer C, Görlitz K, Meimers G, Rizova Y, Blaschke U, Heider C, Cuny C, Drewes S, Heuser E, Jeske K, Jacob J, Ulrich RG, Bocheński M, Kasprzak M, Burda E, Ciepliński M, Kaługa I, Jankowiak Ł, Aguirre JI, López-García A, Höfle U, Jagiello Z, Tobółka M, Janic B, Zieliński P, Kamiński M, Frisch J, Siekiera J, Wendel AF, Brauner P, Jäckel U, Kaatz M, Müller S, Lübke-Becker A, Wieler LH, von Wachsmann J, Thrukonda L, Helal M, Epping L, Wolf SA, Semmler T, Jerzak L.   +47 more
europepmc   +1 more source

∆8-THC, THC-O Acetates and CBD-di-O Acetate: Emerging Synthetic Cannabinoids Found in Commercially Sold Plant Material and Gummy Edibles. [PDF]

J Anal Toxicol, 2022
Holt AK, Poklis JL, Peace MR.
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Comparison of Different Methods of Molecular Detection of Erwinia amylovora in Plant Material. [PDF]

Curr Issues Mol Biol
Pozharskiy A, Kostyukova V, Nizamdinova G, Gritsenko D.   +3 more
europepmc   +1 more source

Plant Material as a Novel Tool in Designing and Formulating Modern Biostimulants-Analysis of Botanical Extract from Linum usitatissimum L. [PDF]

Materials (Basel), 2021
Kocira S, Szparaga A, Krawczuk A, Bartoš P, Zaguła G, Plawgo M, Černý P.   +6 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source