Results 131 to 140 of about 8,310,098 (237)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Maize Transformation: From Plant Material to the Release of Genetically Modified and Edited Varieties. [PDF]

Front Plant Sci, 2021
Yassitepe JECT, da Silva VCH, Hernandes-Lopes J, Dante RA, Gerhardt IR, Fernandes FR, da Silva PA, Vieira LR, Bonatti V, Arruda P.   +9 more
europepmc   +1 more source

Oncogenic DMTF1β promotes cancer cell motility by regulating autophagy through ULK1 stabilization

Molecular Oncology, EarlyView.
In the current study, we demonstrate that the oncogene DMTF1β regulates ULK1 stability by reducing its proteasomal degradation in cancer cells. This stabilization enables ULK1 to induce autophagy, which in turn facilitates cancer cell migration. Consequently, reduced DMTF1β levels lead to decreased autophagy and impaired cancer cell migration.
Jun Xu, Nicolas J. Niklaus, Anna M. Schläfli, Igor Tokarchuk, Magali Humbert, Federico La Manna, Bich Vu, David Maul, Ramin Radpour, Marianna Kruithof‐de Julio, Inti Zlobec, Jörn Dengjel, Bruce E. Torbett, Mario P. Tschan   +13 more
wiley   +1 more source

Integrated Membrane Filtration for the Recovery of Antioxidants from Lavender Spent Plant Material. [PDF]

Membranes (Basel)
Stoyanova Y, Lazarova-Zdravkova N, Pietsch-Braune S, Petrin S, Stefanova A, Heinrich S, Peshev D.   +6 more
europepmc   +1 more source

Supercritical carbon dioxide decellularization of plant material to generate 3D biocompatible scaffolds. [PDF]

Sci Rep, 2021
Harris AF, Lacombe J, Liyanage S, Han MY, Han MY, Wallace E, Karsunky S, Abidi N, Zenhausern F.   +8 more
europepmc   +1 more source

Loss of proton‐sensing TDAG8 increases tumor progression in mouse models of colon cancer

Molecular Oncology, EarlyView.
Loss of the pH‐sensing receptor TDAG8 accelerates colorectal cancer progression in mice. Animals lacking TDAG8 expression had increased tumor growth, DNA damage, and recruitment of tumor‐associated immune cells, including macrophages, neutrophils, and monocytes.
Ermanno Malagola, Yasmine Illi, Anna Bircher, Marijn Wilmink, Rachele F. Malagutti, Solenn Ottié, Cordelia Schuler, Pedro A. Ruiz, Cheryl de Vallière, Klaus Seuwen, Gerhard Rogler, Martin Hausmann   +11 more
wiley   +1 more source

Acinetobacter baumannii's lifestyle includes soil-dwelling colonization of decaying plant material and airborne spread. [PDF]

Nat Commun
Wilharm G, Skiebe E, Michalska A, Higgins PG, Weber K, Schaudinn C, Neugebauer C, Görlitz K, Meimers G, Rizova Y, Blaschke U, Heider C, Cuny C, Drewes S, Heuser E, Jeske K, Jacob J, Ulrich RG, Bocheński M, Kasprzak M, Burda E, Ciepliński M, Kaługa I, Jankowiak Ł, Aguirre JI, López-García A, Höfle U, Jagiello Z, Tobółka M, Janic B, Zieliński P, Kamiński M, Frisch J, Siekiera J, Wendel AF, Brauner P, Jäckel U, Kaatz M, Müller S, Lübke-Becker A, Wieler LH, von Wachsmann J, Thrukonda L, Helal M, Epping L, Wolf SA, Semmler T, Jerzak L.   +47 more
europepmc   +1 more source

∆8-THC, THC-O Acetates and CBD-di-O Acetate: Emerging Synthetic Cannabinoids Found in Commercially Sold Plant Material and Gummy Edibles. [PDF]

J Anal Toxicol, 2022
Holt AK, Poklis JL, Peace MR.
europepmc   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

Comparison of Different Methods of Molecular Detection of Erwinia amylovora in Plant Material. [PDF]

Curr Issues Mol Biol
Pozharskiy A, Kostyukova V, Nizamdinova G, Gritsenko D.   +3 more
europepmc   +1 more source