Results 231 to 240 of about 29,856 (265)

Enhanced Glycolysis‐Driven Histone H3K18 Lactylation Regulates Epileptogenesis by Modulating the E3 Ubiquitin Ligase COP1

Advanced Science, EarlyView.
Neuronal PKM2‐driven glycolysis generates excess lactate that triggers histone H3K18 lactylation (H3K18la), establishing a pathogenic metabolic‐epigenetic axis in epilepsy. Elevated H3K18la enriches the Cop1 promoter, transcriptionally upregulating the E3 ubiquitin ligase COP1, which subsequently drives proteasomal degradation of GABAARβ2 and impairs ...
Yuan Meng, Yanlin Guo, Liumi Jiang, Jing Luo, Yan Liu, Ziwei Yuan, Pingyang Ke, Ran Duan, Fei Xiao   +8 more
wiley   +1 more source

Wheat growth model capturing growth-defense trade-off. [PDF]

Front Plant Sci
Dusfour-Castan P, Buck-Sorlin G, Loisel P, Fontez B, Ballini E.   +4 more
europepmc   +1 more source

Highly Active Cu14 Cluster Precisely Activates Autophagy Inhibitor to Amplify Cuproptosis Immunotherapy

Advanced Science, EarlyView.
An atomically precise Cu14 cluster‐mediated bond scission reaction pioneers the amplification of the antitumor immune response via synergetic cuproptosis‐associated immunogenic cell death induction and in situ autophagy blockade. ABSTRACT Transition metal‐mediated cleavage mechanisms have emerged as an effective means to mitigate the off‐target ...
Qiu‐Xu Zang, Wei‐Tong Chen, Yu‐Ying Shen, Zhao‐Yang Wang, Kai Li, Xueli Zhao, Yanjuan Sang, Xiaoyuan Chen, Shuang‐Quan Zang   +8 more
wiley   +1 more source

Understanding plant resilience by putting photosynthesis and photorespiration in the metabolic context. [PDF]

Planta
Walker BJ, Schroeder WL.
europepmc   +1 more source

Dissecting the Ecological Structure of Health and Disease in the Global Gut Microbiome

Advanced Science, EarlyView.
We introduce Wiredancer, a framework that identifies three continuous ecological factors of the gut microbiota. These factors exhibit distinct patterns across health and disease, jointly capturing disrupted ecological stability and offering a new perspective for precision diagnostics and therapeutic strategies.
Baoyuan Zhu, Shuhao Chen, Yunheng Diao, Wei Wang, Yuanyuan Huang, Liqin Liang, Xiaodan Lu, Rui Han, Minxin Guo, Zhaobo Li, Shuhong Wang, Hehua Li, Chenyu Liu, Jing Zhou, Dongsheng Xiong, Xiaobo Li, Yuping Ning, Xuetao Shi, Fengchun Wu, Kai Wu   +19 more
wiley   +1 more source

Bridging scales: integrated multi-omics and deep phenotyping for climate resilience in crop plants. [PDF]

Front Plant Sci
Anand S, Reddy SB, Shajini NM, Jose E, Shirsat MS, Visakh RL, Jha UC, Sah RP, Beena R.   +8 more
europepmc   +1 more source

The theory of psychic quanta: a quantum model for the unity of individual consciousness. [PDF]

Front Psychol
Tallarico A.
europepmc   +1 more source

Elucidation of Response Mechanism of Potato to Nitrogen Stress by Physiological and Transcriptional Analyses. [PDF]

Genes (Basel)
Ding K, Shan Y, Wang L, Song J, Yang M, Zhang Y, Wang L, Sun X, Li M, Tian G, Li F, Wang H.   +11 more
europepmc   +1 more source

Biomolecular Condensates in Combined and Recurrent Plant Stresses: Integrating Phase Separation, Signal Prioritization, and Cross-Stress Memory. [PDF]

Int J Mol Sci
Ali S, Moon YS.
europepmc   +1 more source

C₂ Resilient Photosynthesis: A Practical Option for Long-Term Stable Carbon Sinks? [PDF]

Biology (Basel)
Zhu J, Chen F.
europepmc   +1 more source