Results 91 to 100 of about 2,977,864 (307)

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

FEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi, João C. Encarnação, Valeria Napolitano, Grzegorz Dubin, Grzegorz Popowicz, Karl Andersson, U. Helena Danielson   +6 more
wiley   +1 more source

Penicillium subrubescens adapts its enzyme production to the composition of plant biomass [PDF]

, 2020
Penicillium subrubescens is able to degrade a broad range of plant biomass and it has an expanded set of Carbohydrate Active enzyme (CAZyme)-encoding genes in comparison to other Penicillium species. Here we used exoproteome and transcriptome analysis to
Hildén, Kristiina S., de Vries, Ronald P., Mäkelä, Miia R., Maria Wilhelmina Hegi, Rosa, Mäkelä, Miia R, Di Falco, Marcos, Molecular Plant Physiology, Sub Molecular Plant Physiology, de Vries, Ronald P, Dilokpimol, Adiphol; id_orcid, Hildén, Kristiina S, Tsang, Adrian, Granchi, Zoraide, Hegi, Rosa M.W., Chin A Woeng, Thomas, Dilokpimol, Adiphol, Peng, Mao, Hegi, Rosa M W   +17 more
core   +2 more sources

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Functional Imaging in living Plants - Cell Biology meets Physiology [PDF]

, 2014
The study of plant cell physiology is currently experiencing a profound transformation. Novel techniques allow dynamic in vivo imaging with subcellular resolution, covering a rapidly growing range of plant cell physiology.
Schwarzländer, Markus, Markus eSchwarzländer, Tobias Meckel, Meckel, Tobias, Costa, Alex, A. Costa, Alex eCosta, Markus Schwarzlander, Littlejohn, George R., Markus Schwarzländer, Tobias eMeckel, Alex Costa, George eLittlejohn, G. R. Littlejohn, George R. Littlejohn, T. Meckel, Schwarzländer, M, M. Schwarzländer   +17 more
core   +1 more source

Ornamental Plant Physiology and Molecular Biology

Horticulturae
Ornamental plants not only beautify our environment, thanks to their vivid colors and diverse forms, but also play a vital role in agriculture, industry, and medicine, reflecting significant scientific and economic value [...]
Tuo Zeng, Caiyun Wang
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Enzymatic Adaptation of Podospora anserina to Different Plant Biomass Provides Leads to Optimized Commercial Enzyme Cocktails [PDF]

, 2018
As a late colonizer of herbivore dung, Podospora anserina has evolved an enzymatic machinery to degrade the more recalcitrant fraction of plant biomass, suggesting a great potential for biotechnology applications.
Lipzen, Anna, Tiziano Benocci, Ng, Vivian, Vivian Ng, Molecular Plant Physiology, Lail, Kathleen, Sub Molecular Plant Physiology, de Vries, Ronald P, Grigoriev, Igor V, Benocci, Tiziano, Ronald P. de Vries, Aguilar‐Pontes, Maria Victoria, Maria Victoria Aguilar‐Pontes, Daly, Paul, Wang, Mei, Mei Wang, Igor V. Grigoriev, Aguilar-Pontes, Maria Victoria, Kathleen Lail, Anna Lipzen, Paul Daly   +20 more
core   +2 more sources

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

To flower or not to flower, a temperature-sensitive decision. Characterization of flowering responses at high ambient temperature in Arabidopsis thaliana [PDF]

, 2015
To maximize fitness, plants use environmental cues to optimize growth processes. One of the processes under strong environmental regulation is flowering. Multiple environmental factors influence flowering, including temperature.
Rodenburg, N., Rodenburg, Nicole, Molecular Plant Physiology, Sub Molecular Plant Physiology   +3 more
core   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source