Results 171 to 180 of about 7,599,772 (310)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Predicting the contribution of single trait evolution to rescuing a plant population from demographic impacts of climate change. [PDF]

Evol Lett
Campbell DR, Powers JM, Kipness J.
europepmc   +1 more source

Altitude, habitat type and herbivore damage interact in their effects on plant population dynamics. [PDF]

PLoS One, 2018
Dostálek T, Rokaya MB, Münzbergová Z.
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Changes in reproduction mediate the effects of climate change and grassland management on plant population dynamics. [PDF]

Ecol Appl
Andrzejak M, Knight TM, Plos C, Korell L.   +3 more
europepmc   +1 more source

Period-3 dominant phase synchronisation of Zelkova serrata: border-collision bifurcation observed in a plant population. [PDF]

Sci Rep, 2019
Sakai K, Hoshino Y, Prasad A, Sugawara Fukamachi A, Ishibashi A.   +4 more
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Tourist Trampling on a Peripheral Plant Population Restricted to an Urban Natural Area in the Capo Sant'Elia Promontory (Sardinia, W-Mediterranean Basin). [PDF]

Plants (Basel)
Cogoni D, Calderisi G, Collu D, Fenu G.
europepmc   +1 more source

Source-to-Sink Translocation of Carbon and Nitrogen Is Regulated by Fertilization and Plant Population in Maize-Pea Intercropping. [PDF]

Front Plant Sci, 2019
Zhao Y, Fan Z, Hu F, Yin W, Zhao C, Yu A, Chai Q.   +6 more
europepmc   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source