Results 161 to 170 of about 7,647,694 (364)

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Species diversity of pests of the suborder of shield bugs (Heteroptera) in agrocenoses of the Lazarevsky district of Sochi, Krasnodar Territory, Russia

Юг России: экология, развитие
Aim. The aim of the work was to study the species diversity of pests of the suborder of shield bugs (Heteroptera) in agrocenoses of the Lazarevsky district of Sochi.This paper presents data on the distribution, abundance and density of Heptoptera pest ...
E. V. Kashutina, L. N. Bugaeva, T. N. Ignatieva   +2 more
doaj   +1 more source

National Aglaw Center Research Article, J.E.M. Ag Supply, Inc. V. Pioneer Hi-bred International, Inc.: its Meaning and Significance for the Agricultural Community [PDF]

, 2009
Biotechnology development in agriculture has raised challenging intellectual property issues. These issues are framed in the context of a three-prong plant patent statutory scheme, involving the Utility Patent Act, the Plant Variety Protection Act, and ...
Roberts, Michael T
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Identification of Fusarium proliferatum chrysovirus 1 and its biocontrol activity of phytopathogenic Fusarium species

Phytopathology Research
Fusarium proliferatum, a pathogenic fungus that causes root rot, poses a significant threat to the yield and quality of Salvia miltiorrhiza. This study introduces Fusarium proliferatum Chrysovirus 1 (FpCV1), a novel mycovirus isolated from strain RZJJ28.
Zhengzhe Guan, Luyang Song, Peimeng Sun, Mengjiao Wang, Mengyuan Zhang, Yuanyuan Zhang, Shaojian Li, Yanhong Qin, Caiyi Wen, Fei Wang, Ying Zhao   +10 more
doaj   +1 more source

Dynamics in crop protection, agriculture and the food chain in Europe [PDF]

, 2001
Overview on the vital role of plant protection in Europe in maintaining and enhancing the dynamics of agricultural production and the food chain. The report offers an overview of the achievements of more sustainable production methods in European ...
Bijman, J., Brouwer, F.M.
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Field application of entomopathogenic agents against the fall armyworm (Spodoptera frugiperda) (J. E. Smith) (Lepidoptera: Noctuidae) in maize

Egyptian Journal of Biological Pest Control
Background Fall armyworm (FAW), Spodoptera frugiperda (J. E. Smith) (Lepidoptera: Noctuidae), larvae have the potential to significantly reduce maize yields.
Ahmed Azazy, Ahmed Adly, Ibrahim El Sappagh, Abdelhalim Khalil, Hassan El-Saadany   +4 more
doaj   +1 more source

The Evolving Landscape of IP Rights for Plant Varieties in the United States, 1930-2008 [PDF]

The United States was the first country in the world to explicitly offer intellectual property protection for plant varieties. Beginning in 1930, asexually reproduced plants were afforded plant patent protection, in 1970 sexually propagated plants could ...
Drew, Jennifer, Koo, Bonwoo, Nottenburg, Carol, Pardey, Philip G.   +3 more
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source