Results 71 to 80 of about 3,180,736 (291)

Decoding the dynamic extracellular matrix in cancer—3D models and bioscaffolds rewire the rules of tumor progression

FEBS Letters, EarlyView.
Cancer progression is regulated by the dynamic matrix code of the tumor microenvironment, which influences cellular behavior and disease development. Importantly, matrix remodeling in three‐dimensional cancer models more accurately reflects in vivo conditions compared to conventional two‐dimensional systems.
Sylvia Mangani, Konstantinos Spanopoulos, Zoi Piperigkou, Nikos K. Karamanos   +3 more
wiley   +1 more source

Chilling consequences: Herbarium records reveal earlier reproductive phenology of winter annual gladecress in a wetter, cooler climate

Plants, People, Planet, 2020
Societal Impact Statement Networks of digitized herbarium records are rich resources for understanding plant responses to climate change. While the climate is warming globally, some localities are experiencing climate cooling, the effects of which are ...
Caitlin Banaszak, Joshua B. Grinath, Christopher R. Herlihy   +2 more
doaj   +1 more source

Butterfly fitness under changing food qualities [PDF]

, 2014
The present thesis investigates how different food qualities over the whole life cycle and across generations affect butterfly development and reproduction, and addresses the following main questions: (1) What effects have varying nitrogen ...
Cahenzli, Fabian
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Physiological Characterization of Two Nicotiana tabacum Lines Differing in Seed Productivity

Plants
Tobacco is a plant with a wet stigma, which produces reactive oxygen species (ROS) and abscisic acid (ABA) which is important for in vivo pollen germination. Furthermore, ROS can be linked to growth processes, stimulating or inhibiting them.
Maria Breygina, Oksana Luneva, Anna Zorina, Anna Podobedova, Tatiana Kalashnikova, Sofia Shaliukhina, Danil Afonin, Dmitry V. Kochkin   +7 more
doaj   +1 more source

Ethylene supports colonization of plant roots by the mutualistic fungus Piriformospora indica [PDF]

, 2012
The mutualistic basidiomycete Piriformospora indica colonizes roots of mono- and dicotyledonous plants, and thereby improves plant health and yield. Given the capability of P.
Jörg Durner, Durner, J., Durner, Jörg, von Wettstein Diter, Schäfer, Patrick, Christian Lindermayr, Behnam Khatabi, Lindermayr, C., Lindermayr Christian, Molitor, A., Lindermayr, Christian, Schäfer Patrick, Jörg Durner (170956), Kogel, K.-H., Karl-Heinz Kogel (54116), Khatabi Behnam, von Wettstein, D., Christian Lindermayr (170953), Pfiffi, S., Diter von Wettstein, Stefanie Pfiffi, Molitor, Alexandra, Kogel, Karl-Heinz, Behnam Khatabi (170951), Diter von Wettstein (136106), Patrick Schäfer, Patrick Schäfer (170961), Schäfer, P., Stefanie Pfiffi (170955), Karl-Heinz Kogel, Molitor Alexandra, Pfiffi Stefanie, Kogel Karl-Heinz, Alexandra Molitor (170952), Alexandra Molitor, Durner Jörg, Wettstein, Diter von, Khatabi, B., Khatabi, Behnam, Pfiffi, Stefanie   +39 more
core   +2 more sources

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Engineering Biomimetic Sporangia in Land Plants

Bioengineering
The land plant sporangium is unique in its ability to initiate differentiation of the reproductive germ line, leading directly to meiosis and the formation of eggs and sperm; but our lack of understanding of the processes underlying gametogenesis in ...
Matthew S. Grasso, Rachael Floreani, Philip M. Lintilhac   +2 more
doaj   +1 more source

Identification of Bottlenecks in the Plant Life Cycle for Sustainable Conservation of Rare and Endangered Species

Frontiers in Ecology and Evolution, 2017
Long term survival of a species relies on maintenance of genetic variability and natural selection by means of successful reproduction and generation turnover.
Giovanna Aronne
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source