Results 51 to 60 of about 78,108 (333)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Bioactive Potential of 3D-Printed Oleo-Gum-Resin Disks: B. papyrifera, C. myrrha, and S. benzoin Loading Nanooxides—TiO2, P25, Cu2O, and MoO3

Bioinorganic Chemistry and Applications, 2017
This experimental study investigates the bioactive potential of filaments produced via hot melt extrusion (HME) and intended for fused deposition modeling (FDM) 3D printing purposes.
Diogo José Horst, Sergio Mazurek Tebcherani, Evaldo Toniolo Kubaski, Rogério de Almeida Vieira   +3 more
doaj   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Analytical methods applied to diverse types of Brazilian propolis

Chemistry Central Journal, 2011
Propolis is a bee product, composed mainly of plant resins and beeswax, therefore its chemical composition varies due to the geographic and plant origins of these resins, as well as the species of bee.
Marcucci Maria, Barbosa da Silva Cunha Ildenize, Sawaya Alexandra   +2 more
doaj   +1 more source

Progress and bottlenecks in the early domestication of the perennial oilseed Silphium integrifolium, a sunflower substitute [PDF]

, 2018
Silflower (Silphium integrifolium Michx.) is in the early stages of domestication as a perennial version of oilseed sunflower, its close relative. Grain crops with deep perennial root systems will provide farmers with new alternatives for managing soil ...
Crews, Timothy E., González Paleo, Luciana, Peterson, Kelsey, Ravetta, Damián Andrés, Turner, Kathryn, Van Tassel, David, Vilela, Alejandra Elena   +6 more
core   +2 more sources

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

EXTRACTION AND SEPARATION OF SOME ACTIVE COMPOUNDS IN ERUCA SATIVA AND STIUDY IT'S BIOLOGICAL ACTIVITY [PDF]

مجلة جامعة الانبار للعلوم الصرفة, 2014
This study aimed to sperat and extract of some active compounds in Eruca sativa .It included identificaion and determination of active compounds their percentages in the leaves,stem and seeds,like(Tannine, Glycosides,Alkaloids,Saponins,Resins,Flavonoids ...
MOHAMMED HAMEED – AL MOHAMMDI, WAJEEH YUNAS AL- ANI   +1 more
doaj   +1 more source

SmallTalk: a novel small‐sized fusion tag for peptide expression and purification

FEBS Open Bio, EarlyView.
The SmallTalk fusion tag allows for the efficient expression and purification of soluble recombinant proteins or peptides in Escherichia coli. Testing with SmallTalk‐GFP confirmed that the proteins were soluble and folded correctly, while SmallTalk‐Bin1b maintained its antimicrobial activity against various bacterial isolates. This streamlined workflow
Atika Tariq, Nestor G. Casillas‐Vega, Alma Gomez‐Loredo, Xristo Zarate   +3 more
wiley   +1 more source

Electrochemically treated lignin in phenolic resins for plywood panels

Sustainable Chemistry for the Environment, 2023
In achieving the European Union's goal of making Europe the first climate-neutral continent by 2050, the scientific community is striving to develop processes and products that are technologically and economically sustainable to replace/substitute fossil-
Electra Papadopoulou, Theresa Rücker, Zoe Nikolaidou, Sotirios Kountouras, Themistoklis Sevastiadis, Torbjørn Pettersen, Bernd Wittgens   +6 more
doaj   +1 more source

NR4A1 Exerts Pro‐Tumor Role in Glioblastoma via Inducing xCT/GPX4‐Regulated Ferroptosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Purpose This study investigates NR4A1's paradoxical roles in glioblastoma (GBM) progression, focusing on its mechanistic link to ferroptosis regulation. We aimed to resolve conflicting reports of NR4A1 as both an oncogene and a tumor suppressor by defining its transcriptional control over xCT/GPX4‐mediated iron homeostasis and its clinical ...
Peng Tao, Shikuan Din, Zhengkang Fu, Qian Sun, Xiwei Zhu, Yuxin Wei, Huan Qu, Xinyi Zhang, Jiaxuan Liu, Chuhua Fu, Qianxue Chen   +10 more
wiley   +1 more source