Results 211 to 220 of about 753,464 (253)

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

Molecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel, Izabela Kubiak, Lena Rutkowska, Żaneta Kasprzyk, Łukasz Kępczyński, Michał Bednarek, Dariusz Sobieraj, Jacek Wilkosz, Piotr Kania, Adam Jędrzejczyk, Bogdan Kałużewski, Agnieszka Gach, Tadeusz Kałużewski   +12 more
wiley   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Application of Single-Cell Assay for Transposase-Accessible Chromatin with High Throughput Sequencing in Plant Science: Advances, Technical Challenges, and Prospects. [PDF]

Int J Mol Sci
Lu C, Wei Y, Abbas M, Agula H, Wang E, Meng Z, Zhang R.   +6 more
europepmc   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

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Multivariate approaches in plant science

Phytochemistry, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
David M, Gottlieb, Jakob, Schultz, Susanne W, Bruun, Susanne, Jacobsen, Ib, Søndergaard   +4 more
openaire   +2 more sources

Carbohydrate Microarrays in Plant Science

2012
Almost all plant cells are surrounded by glycan-rich cell walls, which form much of the plant body and collectively are the largest source of biomass on earth. Plants use polysaccharides for support, defense, signaling, cell adhesion, and as energy storage, and many plant glycans are also important industrially and nutritionally.
Fangel, Jonatan Ulrik, Pedersen, Henriette Lodberg, Vidal Melgosa, Silvia, Ahl, Louise Isager, Asunción Salmeán, Armando, Madsen, Jack Egelund, Rydahl, Maja Gro, Clausen, Mads Hartvig, Willats, William George Tycho   +8 more
openaire   +3 more sources

Plant science in the age of phage

Trends in Plant Science, 2004
A wide range of foreign proteins can be expressed at the surface of bacteriophage particles by fusion to phage coat proteins. This powerful molecular technique, known as phage display, has been embraced by the animal and medical research communities but has received less attention from plant scientists.
Bernal Giraldo, Adriana Jimena, Willats, William George Tycho   +1 more
openaire   +2 more sources

Science diplomacy for plant health

Nature Plants, 2020
Peer ...
Baldissera Giovani, Sylvia Blümel, Ralf Lopian, David Teulon, Stephanie Bloem, Cristina Galeano Martínez, Camilo Beltrán Montoya, Carlos Ramon Urias Morales, Sridhar Dharmapuri, Visoni Timote, Nico Horn, Mekki Chouibani, Jean Gérard Mezui M’Ella, Veronica Herrera, Aurélie Castinel, Con Goletsos, Carina Moeller, Ian Naumann, Giuseppe Stancanelli, Stef Bronzwaer, Sara Tramontini, Philip MacDonald, Loren Matheson, Géraldine Anthoine, Kris De Jonghe, Martijn Schenk, Silke Steinmöller, Elena Rodriguez, Maria Leonor Cruz, Jo Luck, Greg Fraser, Sarah Brunel, Mirko Montuori, Craig Fedchock, Elspeth Steel, Helen Grace Pennington, Roger Day, Jean Pierre Rossi, Jingyuan Xia   +38 more
openaire   +5 more sources

A New Focus on Plant Sciences

Science, 2010
Plants are essential to the survival of our planet—to its ecology, biodiversity, and climate. They maintain human health by providing the basis for nutrition, shelter, clothing, and energy. The study of plants has yielded fundamental insights that have reshaped our understanding of the world and has enabled major human needs to be addressed.
Steven J, McCormick, Robert, Tjian
openaire   +2 more sources