Results 211 to 220 of about 755,864 (252)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Application of Single-Cell Assay for Transposase-Accessible Chromatin with High Throughput Sequencing in Plant Science: Advances, Technical Challenges, and Prospects. [PDF]

Int J Mol Sci
Lu C, Wei Y, Abbas M, Agula H, Wang E, Meng Z, Zhang R.   +6 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

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Multivariate approaches in plant science

Phytochemistry, 2004
AbstractFor Abstract see ChemInform Abstract in Full Text.
David M, Gottlieb, Jakob, Schultz, Susanne W, Bruun, Susanne, Jacobsen, Ib, Søndergaard   +4 more
openaire   +2 more sources

A New Focus on Plant Sciences

Science, 2010
Plants are essential to the survival of our planet—to its ecology, biodiversity, and climate. They maintain human health by providing the basis for nutrition, shelter, clothing, and energy. The study of plants has yielded fundamental insights that have reshaped our understanding of the world and has enabled major human needs to be addressed.
Steven J, McCormick, Robert, Tjian
openaire   +2 more sources

Carbohydrate Microarrays in Plant Science

2012
Almost all plant cells are surrounded by glycan-rich cell walls, which form much of the plant body and collectively are the largest source of biomass on earth. Plants use polysaccharides for support, defense, signaling, cell adhesion, and as energy storage, and many plant glycans are also important industrially and nutritionally.
Fangel, Jonatan Ulrik, Pedersen, Henriette Lodberg, Vidal Melgosa, Silvia, Ahl, Louise Isager, Asunción Salmeán, Armando, Madsen, Jack Egelund, Rydahl, Maja Gro, Clausen, Mads Hartvig, Willats, William George Tycho   +8 more
openaire   +3 more sources

Plant science in the age of phage

Trends in Plant Science, 2004
A wide range of foreign proteins can be expressed at the surface of bacteriophage particles by fusion to phage coat proteins. This powerful molecular technique, known as phage display, has been embraced by the animal and medical research communities but has received less attention from plant scientists.
Bernal Giraldo, Adriana Jimena, Willats, William George Tycho   +1 more
openaire   +2 more sources

Science diplomacy for plant health

Nature Plants, 2020
Peer ...
Baldissera Giovani, Sylvia Blümel, Ralf Lopian, David Teulon, Stephanie Bloem, Cristina Galeano Martínez, Camilo Beltrán Montoya, Carlos Ramon Urias Morales, Sridhar Dharmapuri, Visoni Timote, Nico Horn, Mekki Chouibani, Jean Gérard Mezui M’Ella, Veronica Herrera, Aurélie Castinel, Con Goletsos, Carina Moeller, Ian Naumann, Giuseppe Stancanelli, Stef Bronzwaer, Sara Tramontini, Philip MacDonald, Loren Matheson, Géraldine Anthoine, Kris De Jonghe, Martijn Schenk, Silke Steinmöller, Elena Rodriguez, Maria Leonor Cruz, Jo Luck, Greg Fraser, Sarah Brunel, Mirko Montuori, Craig Fedchock, Elspeth Steel, Helen Grace Pennington, Roger Day, Jean Pierre Rossi, Jingyuan Xia   +38 more
openaire   +5 more sources