Results 101 to 110 of about 37,805 (261)

Weakening the nuclear envelope: Lamin B receptor in melanoma metastasis

Molecular Oncology, EarlyView.
LBR‐driven nuclear fragility supports melanoma invasion. A: Melanocyte presents low LBR (Lamin B Receptor) levels, maintaining nuclear integrity and lamina‐chromatin tethering. B: During malignant progression, upregulation of LBR clusters at the INM (Inner Nuclear Membrane) during confined migration causes local lamina weakening and cholesterol ...
Francesca Lorenzini, Maria Caterina Mione   +1 more
wiley   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

Molecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski, Liudmyla Dolinchuk, Michał Jerzak, Albert Gandurski, Tomasz Grochowski, Weronika Wojtyś, Maciej Zadrożny, Wojciech Kaźmierczak, Małgorzata Lenarcik, Marta Matejak‐Górska, Radosław Samsel, Tomasz Olesiński, Dawid Walerych   +12 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

Morphological characteristics, dry matter yield, and nutritive value of maralfalfa grass (Pennisetum spp.) grown under different planting densities in the central highlands of Ethiopia

Frontiers in Animal Science
IntroductionMaralfalfa grass (Pennisetum spp.) is known for its high dry matter productivity and nutritive value. However, information on agronomic management practices to improve yield and nutritive value in Ethiopia is sparse.Materials and methodThe ...
Gezahegn Mengistu, Gezahagn Kebede, Mulisa Faji, Fekede Feyissa, Kedir Mohammed, Aemiro Kehaliew, Diriba Geleti, Muluneh Minta, Mulubrhan Balehegn, Mulubrhan Balehegn, Estebah F. Rios, Adegbola T. Adesogan, Adegbola T. Adesogan, Jose C. B. Dubeux, Kenneth J. Boote   +14 more
doaj   +1 more source

Effect of Plant Spacing on Yield and Yield Components of Tomato (Solanum lycopersicum L.) in Shewarobit, Central Ethiopia. [PDF]

Scientifica (Cairo), 2020
Amare G, Gebremedhin H.
europepmc   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Initial Validation of NPK Fertilizer Rates and Plant Spacing for Morkhor 60, a New Soybean Variety, in Sandy Soils: Enhancing Yield and Economic Returns

Agriculture
Soybeans (Glycine max (L.) Merr.) are a vital global crop; however, Thailand currently imports 99% of its domestic requirement, highlighting the critical need for enhanced domestic production.
Thanaphon Patjaiko, Tidarat Monkham, Jirawat Sanitchon, Sompong Chankaew   +3 more
doaj   +1 more source

Corrigendum to "Effect of Plant Spacing on Yield and Yield Components of Tomato (Solanum lycopersicum L.) in Shewarobit, Central Ethiopia". [PDF]

Scientifica (Cairo), 2020
Amare G, Gebremedhin H.
europepmc   +1 more source