Results 51 to 60 of about 576,731 (309)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Molecules, 2021 Efforts to develop the necessary biotechnologies in Greater Celandine (Chelidonium majus L.), a leading plant resource for the development of plant-derived medicines, have been hampered by the lack of knowledge about transcriptome and metabolome ...
Seyed Mohammad Hashemi +5 more
doaj +1 more source
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
MoleculesThe mycelia of Hericium erinaceus contain neuroprotective cyathane diterpenoids (e.g., erinacine A). There is evidence that cultivation of submerged mycelia with surfactants increases glucose uptake and biomass, but the impact on erinacine production is ...
Abigail Veronica Smith +3 more
doaj +1 more source
Development of locomotion over inclined surfaces in laying hens
Animal, 2018 The purpose of the present study was to evaluate locomotor strategies during development in domestic chickens (Gallus gallus domesticus); we were motivated, in part, by current efforts to improve the design of housing systems for laying hens which aim to
C. LeBlanc +3 more
doaj +1 more source
Contemporaneity of Spain rural architecture intervention and economic sustainability [PDF]
, 2017 From the second half of the 20th century onwards, Spanish rural architecture has suffered a transformation regarding its farming and ranching model. The economic unsustainability of the family economy has led to further action for the viability of the ...
Curós i Vilà, Joan +1 more
core +3 more sources
Utilization of tourmaline stone as a fertilizer in medicinal plant verticulture
Community Empowerment, 2021 Citizen activities towards the community which will be carried out by non-people groups in Jati Village, Jaten District, Karanganyar Regency. The location is classified as Peri-Urban area, where agricultural land has been largely over the function of land, the number of people who do the transfer of professions from the agricultural sector to the ...
Umi Barokah +4 more
openaire +1 more source
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Journal of Lithic Studies, 2020 Ground stone implements are found across most Australian landscapes and are often regarded as Aboriginal tools that were used for processing or modifying other items such as plant foods, plant fibres, resins, bone points, pigments and ground-stone axes ...
Elspeth Hayes +5 more
doaj +1 more source