Results 141 to 150 of about 190,892 (265)

Pharmacologic Modulation of ARID3A with Rimegepant Reactivates Type I Interferon Signaling and Sensitizes Triple‐Negative Breast Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
This study identifies ARID3A as a key immunosuppressive transcription factor in TNBC. Its inhibition activates the type I IFN pathway, boosting CD8+ T cell infiltration and sensitizing tumors to anti‐PD‐1. The FDA‐approved migraine drug Rimegepant targets ARID3A, enhances immunotherapy efficacy in preclinical models, and establishes a druggable axis to
Teng Zhou, Yifei Zhu, Cheng Zeng, Jinlu Han, Huiying Huang, Doudou Li, Mingxi Lin, Yizi Jin, Qin Guo, Yuxin Yan, Xinhui Mao, Yifei Zhou, Jian Zhang   +12 more
wiley   +1 more source

Plant traits explain variation in symbiotic nitrogen fixation responses to global nitrogen enrichment: a meta-analysis. [PDF]

Nat Commun
Yao Y, Han B, Bodegom PMV, Dong X, Zhong Y, Niu S, Chen X, Li Z.   +7 more
europepmc   +1 more source

Plant Traits Guide Species Selection in Vegetation Restoration for Soil and Water Conservation. [PDF]

Biology (Basel), 2023
Fu D, Wu X, Hu L, Ma X, Shen C, Shang H, Huang G, He Y, Duan C.   +8 more
europepmc   +1 more source

Haplotype‐Resolved 3D Genomic Landscapes and Their Impacts on Agronomic Traits in Grapevine

Advanced Science, EarlyView.
This study presents a haplotype‐resolved 3D genomic landscape of grapevine, revealing that structural variations (SVs) are closely associated with phased topologically associating domain (TAD) boundary transitions. These rearrangements coordinate with allele‐specific DNA methylation (ASM) and allele‐biased gene expression (ASE) to shape key agronomic ...
Yanling Peng, Lianzhu Zhou, Xinyue Fang, Ruoyan Zhao, Qi Xu, Mengrui Du, Ting Hou, Guizhou Huang, Yingchun Zhang, Sheng Yan, Ruo Yang, Zhongxin Jin, Yang Dong, Yanshuai Xu, Hua Xiao, Xiaodong Xu, Yi Liao, Xiping Wang, Yongfeng Zhou   +18 more
wiley   +1 more source

Plant traits and associated ecological data from Afromontane grasslands of Maloti-Drakensberg, South Africa. [PDF]

Sci Data
Halbritter AH, Vandvik V, Bison NN, Clark VR, Cross M, Greve M, Kemppinen J, Kühn N, Maitner BS, Michaletz ST, Navarro J, Niittynen P, le Roux PC, White JDM, Abebe BY, Arzt NM, Baldaszti L, Aragón L, Beale S, Birkeli K, Courtenay AP, Dawson HR, Draganova LK, Gillespie LE, Goff KA, Gowera ATD, Gualdoni-Becerra A, Gwate O, Hagenberg LWC, Hansda P, Harris R, Lee J, Louw MA, Määttänen AM, Malamud N, Malekana L, Mc Millan B, Rabi N, Mustri M, Mekasha S, Shemsu Nasir S, Navarro-Rosales F, Ofosu-Bamfo B, Phiri AZ, Rentier ES, Vázquez-Ribera C, Rivas G, Satriawan TW, Smit IC, Soremi PAS, Stokka RS, Šubrt J, Trepel J, Wieczorkowski JD, Enquist BJ.   +54 more
europepmc   +1 more source

Plant traits and associated data from a warming experiment, a seabird colony, and along elevation in Svalbard. [PDF]

Sci Data, 2023
Vandvik V, Halbritter AH, Althuizen IHJ, Christiansen CT, Henn JJ, Jónsdóttir IS, Klanderud K, Macias-Fauria M, Malhi Y, Maitner BS, Michaletz S, Roos RE, Telford RJ, Bass P, Björnsdóttir K, Bustamante LLV, Chmurzynski A, Chen S, Haugum SV, Kemppinen J, Lepley K, Li Y, Linabury M, Matos IS, Neto-Bradley BM, Ng M, Niittynen P, Östman S, Pánková K, Roth N, Castorena M, Spiegel M, Thomson E, Vågenes AS, Enquist BJ.   +34 more
europepmc   +1 more source

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

FAIRTraits: An enriched, FAIR-compliant database of plant traits from Mediterranean populations of 240 species. [PDF]

Ecology
Garnier É, Delalandre L, Segrestin J, Barkaoui K, Kazakou E, Navas ML, Vile D, Violle C, Bernard-Verdier M, Birouste M, Blanchard A, Bumb I, Cruz P, Debain S, Fayolle A, Fortunel C, Grigulis K, Laurent G, Lavorel S, Lloret F, Pérez-Ramos IM, Prieto I, Roumet C.   +22 more
europepmc   +1 more source

Plant traits poorly predict winner and loser shrub species in a warming tundra biome. [PDF]

Nat Commun, 2023
García Criado M, Myers-Smith IH, Bjorkman AD, Normand S, Blach-Overgaard A, Thomas HJD, Eskelinen A, Happonen K, Alatalo JM, Anadon-Rosell A, Aubin I, Te Beest M, Betway-May KR, Blok D, Buras A, Cerabolini BEL, Christie K, Cornelissen JHC, Forbes BC, Frei ER, Grogan P, Hermanutz L, Hollister RD, Hudson J, Iturrate-Garcia M, Kaarlejärvi E, Kleyer M, Lamarque LJ, Lembrechts JJ, Lévesque E, Luoto M, Macek P, May JL, Prevéy JS, Schaepman-Strub G, Sheremetiev SN, Siegwart Collier L, Soudzilovskaia NA, Trant A, Venn SE, Virkkala AM.   +40 more
europepmc   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source