Results 191 to 200 of about 2,505,534 (253)

Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?

open access: yesBritish Journal of Pharmacology, EarlyView.
Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli   +7 more
wiley   +1 more source

Therapeutic access points: The roles of circumventricular organs in drug delivery and metabolic regulation

open access: yesBritish Journal of Pharmacology, EarlyView.
The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral   +3 more
wiley   +1 more source

Mapping the Tissue Architecture and Endothelial‐PEC Network in HAML Using Single‐Cell and Spatial Transcriptomics

open access: yesCancer Science, EarlyView.
Spatial multi‐omics mapping of hepatic angiomyolipoma reveals that PEComas tightly co‐localize with endothelial cells, which drive autophagic flux in adjacent tumor cells via a paracrine PDGFD–PDGFRB–Ras axis, establishing a compensatory survival network that operates in parallel to canonical TSC–mTOR defects.
Xinyang Liu   +9 more
wiley   +1 more source

Evaluating a structured expert elicitation approach for adaptive conservation management based on lessons from five years in practice

open access: yesConservation Biology, EarlyView.
Abstract Adaptive management of threatened species relies on having ex ante estimates of species’ responses to different interventions. Structured expert elicitation is often used to generate these estimates, but comparisons of these expert‐predicted outcomes with observed results are rare.
Helen J. Mayfield   +18 more
wiley   +1 more source

Seed Potato Bacteria Transfer Across Generations Within the Tuber Flesh. [PDF]

open access: yesMicrob Ecol
Saha S   +4 more
europepmc   +1 more source

Climate shocks, coping strategies, and household resilience: Evidence from a three‐wave panel in Malawi

open access: yesContemporary Economic Policy, EarlyView.
Abstract Climate shocks threaten rural livelihoods in Malawi, yet households adopt diverse coping strategies to mitigate welfare losses. Using three‐wave Living Standards Measurement Study–Integrated Surveys on Agriculture panel data (2013–2019) and household fixed‐effects models, this study examines how climate shocks affect food security and ...
Suyeon Ro, Jongwook Lee
wiley   +1 more source

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