Results 111 to 120 of about 56,042 (301)

Poly(lactic‐co‐glycolic acid) Nanoparticles for IL‐12 Self‐Amplifying RNA Delivery in Glioblastoma Models

Advanced Functional Materials, EarlyView.
xxxx. ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain cancers, with median survival rarely exceeding 15 months after diagnosis. Interleukin‐12 (IL‐12) is a potent immunostimulatory cytokine capable of reshaping the tumor microenvironment (TME), yet its clinical translation is hindered by systemic toxicity and short half‐life. RNA‐based
Fatima Hameedat, Johan Sebastian Lopez‐Parra, Willem M. H. Hoogaars, Emma Dijkstra, Cynthia Huang, Irafasha C. Casmil, Anna K. Blakney, Peter Olinga, Barbara Rothen‐Rutishauser, Hélder A. Santos, Alke Petri‐Fink, Flávia Sousa   +11 more
wiley   +1 more source

Transgenic Plants Expressing Geminivirus Movement Proteins: Abnormal Phenotypes and Delayed Infection by Tomato mottle virus in Transgenic Tomatoes Expressing the Bean dwarf mosaic virus BV1 or BC1 Proteins

Molecular Plant-Microbe Interactions, 2000
Transgenic tomato plants expressing wild-type or mutated BV1 or BC1 movement proteins from Bean dwarf mosaic virus (BDMV) were generated and examined for phenotypic effects and resistance to Tomato mottle virus (ToMoV).
Yu-Ming Hou, Rick Sanders, Virgina M. Ursin, Robert L. Gilbertson   +3 more
doaj   +1 more source

Insertion and Topology of a Plant Viral Movement Protein in the Endoplasmic Reticulum Membrane [PDF]

, 2002
Marçal Vilar, Ana Saurı́, Magnus Monné, José F. Marcos, Gunnar von Heijne, Enríque Pérez‐Payá, Ismael Mingarro   +6 more
openalex   +1 more source

Membrane Fusion‐Inspired Nanomaterials: Emerging Strategies for Infectious Disease and Cancer Diagnostics

Advanced Healthcare Materials, EarlyView.
Membrane fusion‐inspired nanomaterials offer transformative potential in diagnostics by mimicking natural fusion processes to achieve highly sensitive and specific detection of disease biomarkers. This review highlights recent advancements in nanomaterial functionalization strategies, signal amplification systems, and stimuli‐responsive fusion designs,
Sojeong Lee, Khulan Nyamzaya, Jueun Han, Yejin Song, Jihee Lee, Jung Hyun Jo, Seungmin Bang, Eun‐Kyung Lim, Seungjoo Haam, Eunjung Kim   +9 more
wiley   +1 more source

Natural history of Arabidopsis thaliana and oomycete symbioses [PDF]

, 2008
Molecular ecology of plant–microbe interactions has immediate significance for filling a gap in knowledge between the laboratory discipline of molecular biology and the largely theoretical discipline of evolutionary ecology.
A. Falk, A. H. Ellingboe, A. H. Ellingboe, A. J. Slusarenko, A. P. Rehmany, A. P. Rehmany, A. Riethmüller, A. Roetschi, Arabidopsis Genome Initiative, B. F. Holt, B. M. Tyler, C. Azevedo, C. D. Preston, C. Damgaard, D. Jirage, E. B. Holub, E. B. Holub, E. B. Holub, E. B. Holub, E. B. Holub, E. B. Holub, E. B. Holub, E. B. Holub, E. G. Bakker, E. Gäumann, E. Koch, E. O. Wilson, E. Speulman, Eric B. Holub, G. Lindau, H. Jönsson, H. Takahashi, H. Voglmayr, H.-M. Chou, J. E. Parker, J. E. Parker, J. Glazebrook, J. Glazebrook, J. M. McDowell, J. M. McDowell, J. N. Thompson, J. N. Thompson, J. N. Thompson, J. O. Borevitz, J. Silvertown, J. Song, J. Staal, J. Win, K. A. Shen, K. Century, K. Kazan, K. Lawton, K. S. Century, K. S. Thompson, L. E. Rose, M. A. Botella, M. A. Botella, M. B. Cooley, M. Damme Van, M. G. M. Aarts, M. Göker, M. H. Borhan, M. H. Borhan, M. J. Austin, M. Tör, N. Aarts, N. Gunn, O. Constantinescu, P. Ayers, P. D. Bittner-Eddy, P. Prusinkiewicz, P. R. Muskett, P. Tornero, Q. H. Shen, R. F. Warren, R. F. Warren, R. Gomulkiewicz, R. L. Allen, R. M. Clark, S. Kamoun, S. McCouch, S. R. Grant, S. Segal, T. Eulgem, T. Eulgem, T. Mitchell-Olds, W. Gassmann, X. Tang   +87 more
core   +2 more sources

A Human Kidney Tubuloid Model of Repeated Cisplatin‐Induced Cellular Senescence and Fibrosis for Drug Screening

Advanced Healthcare Materials, EarlyView.
Replicating aging and senescence‐related pathophysiological responses in kidney organoids remains a significant challenge. Human adult renal tubular organoid, tubuloids, are successfully developed recapitulating cellular senescence that is the central pathophysiological mechanism of chronic kidney disease (CKD).
Yuki Nakao, Makiko Mori, Yuta Sekiguchi, Iori Morita, Ryota Shindoh, Shintaro Mandai, Tamami Fujiki, Hiroaki Kikuchi, Fumiaki Ando, Koichiro Susa, Takayasu Mori, Ayumi Suzuki, Yuji Nashimoto, Hirokazu Kaji, Yuma Waseda, Soichiro Yoshida, Yasuhisa Fujii, Eisei Sohara, Shinichi Uchida, Kensuke Miyake, Yutaro Mori   +20 more
wiley   +1 more source

Transgenic resistance to PMTV and PVA provides novel insights to viral long-distance movement [PDF]

, 2005
The studies in this thesis describe forms of transgenic resistance to plant viruses and how they can be used for studying viral infection cycle. S. tuberosum cv.
Germundsson, Anna
core  

Ultrasound‐Triggered Gelation for Restoring Biomechanical Properties of Degenerated Functional Spinal Units

Advanced Healthcare Materials, EarlyView.
This study introduces an innovative approach to treating intervertebral disc degeneration using ultrasound‐triggered in situ hydrogel formation. Proof‐of‐concept experiments using optimized biomaterial and ultrasound parameters demonstrate partial restoration of biomechanical function and successful integration into degenerated disc tissue, offering a ...
Veerle A. Brans, Anna P. Constantinou, Matthew J. Kibble, Valeria Nele, Daniel Reumann, Luca Bau, Sebastien J. P. Callens, James P. K. Armstrong, Nicolas Newell, Constantin C. Coussios, Molly M. Stevens, Michael D. Gray   +11 more
wiley   +1 more source

The Coat Protein of Citrus Yellow Vein Clearing Virus Interacts with Viral Movement Proteins and Serves as an RNA Silencing Suppressor

Viruses, 2019
Citrus yellow vein clearing virus is a newly accepted member of the genus Mandarivirus in the family Alphaflexiviridae. The triple gene block proteins (TGBp1, TGBp2 and TGBp3) encoded by plant viruses in this family function on facilitating virus ...
Atta Ur Rehman, Zhuoran Li, Zuokun Yang, Muhammad Waqas, Guoping Wang, Wenxing Xu, Feng Li, Ni Hong   +7 more
doaj   +1 more source

Advances in Bioprinting to Model Immune‐Mediated Skin Diseases

Advanced Healthcare Materials, EarlyView.
This review explores how 3D bioprinting drives innovation in developing in vitro skin models that mimic immune‐mediated diseases. It highlights current technologies, key applications in studying skin pathologies, and emerging challenges. The review points toward future opportunities for improving disease modeling and advancing therapeutic and cosmetic ...
Andrea Ulloa‐Fernández, Marica Markovic, Julia Fernández‐Pérez, Georg Stary, Aleksandr Ovsianikov   +4 more
wiley   +1 more source