Results 101 to 110 of about 11,010,391 (302)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Water in the 2000 Virginia General Assembly

, 2000
The Virginia General Assembly held its 2000 session from January 12 to March 10. Lawmakers considered 3,172 bills and resolutions (compared to 2,735 measures considered in 1999).
Virginia Water Resources Research Center
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Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Plant electrophysiological responses to drought and their association with live fuel moisture and flammability in Salvia rosmarinus

Plant Signaling & Behavior
Live fuel moisture content is a key determinant of live fuel flammability, yet its destructive and discontinuous measurement limits high-temporal-resolution monitoring.
David Fuente, Rodolfo Zapata, Ernesto Martínez-Heras, Maria Dolores Raigón, Jose-Vicente Oliver-Villanueva   +4 more
doaj   +1 more source

Relationship between Plant Water Status and Water Movement in Tomato.

Engei Gakkai zasshi, 1993
Water economy between leaf and fruit in tomato plant was studied to establish a water management practice based on plant water status.1. Relationships among stem, leaf, and fruit water potentials in tomato plants are influ- enced by soil moisture status.
openaire   +2 more sources

Problems Associated with Measuring Plant Water Status [PDF]

HortScience, 1990
The water status of plant cells affects physiological and metabolic activities as well as expansion and growth. Accurate measurements of plant water status are essential for a better understanding of productivity under various environmental conditions.
openaire   +1 more source

Towards spatial assessment of carbon sequestration in peatlands: spectroscopy based estimation of fractional cover of three plant functional types [PDF]

, 2008
Peatlands accumulated large carbon (C) stocks as peat in historical times. Currently however, many peatlands are on the verge of becoming sources with their C sequestration function becoming sensitive to environmental changes such as increases in ...
G. Schaepman-Strub, Bartholomeus, H M, M. Menken, Menken, M, J. Limpens, Schaepman, M.E., Bartholomeus, H. M., Schaepman-Strub, G, Schaepman, Michael E; https://orcid.org/, H. M. Bartholomeus, Schaepman, M. E., M. E. Schaepman, Bartholomeus, H., Limpens, J, Schaepman-Strub, G., Limpens, J., Menken, M., Schaepman-Strub, Gabriela   +17 more
core   +2 more sources

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Pullman Moscow Water Resources Committee Status Report

, 1969
The report provides an update of the ground water supply in the Pullman Moscow basin, further development of the water resources of the basin, and the possible ...
Pullman Moscow Water Resources Committee
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Woody Biochar Differently Influences Plant Water Status and Growth of Five Quinoa (Chenopodium Quinoa Willd.) Varieties Under Water Stress [PDF]

Only few studies have evaluated the responses of quinoa varieties to biochar amendment under water-limited conditions during the early growth stages.
Fulai Liu, Christian Andreasen, Andreasen, Christian, Muhammad Zubair Akram, Angela Libutti, Anna Rita Rivelli, Liu, Fulai, Rivelli, Anna Rita, Akram, Muhammad Zubair, Libutti, Angela   +9 more
core   +1 more source