Results 71 to 80 of about 543,977 (261)
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Silicon Supplementation Alleviates the Salinity Stress in Wheat Plants by Enhancing the Plant Water Status, Photosynthetic Pigments, Proline Content and Antioxidant Enzyme Activities. [PDF]
Plants (Basel), 2022 Singh P +8 more
europepmc +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Influence of nocturnal water dynamics on gas exchange and biomass accumulation in hydroponic basil
Scientia HorticulturaePlant growth is dependent on water status, which can be manipulated by altering the water potential in the root zone or modifying atmospheric humidity around shoots.
Wachira Suwannarut +3 more
doaj +1 more source
Terahertz time domain spectroscopy allows contactless monitoring of grapevine water status
Frontiers in Plant Science, 2015 Agriculture is the sector with the greatest water consumption, since food production is frequently based on crop irrigation. Proper irrigation management requires reliable information on plant water status, but all the plant-based methods to determine it
Luis Gonzaga Santesteban +5 more
doaj +1 more source
Relationship between Plant Water Status and Water Movement in Tomato.
Engei Gakkai zasshi, 1993 Water economy between leaf and fruit in tomato plant was studied to establish a water management practice based on plant water status.1. Relationships among stem, leaf, and fruit water potentials in tomato plants are influ- enced by soil moisture status.
openaire +2 more sources
Problems Associated with Measuring Plant Water Status [PDF]
HortScience, 1990 The water status of plant cells affects physiological and metabolic activities as well as expansion and growth. Accurate measurements of plant water status are essential for a better understanding of productivity under various environmental conditions.
openaire +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source