Results 101 to 110 of about 406,766 (256)

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

Leaf tensity: a method for rapid determination of water requirement information in Brassica napus L.

Journal of Plant Interactions, 2018
Water regulation caused by enzymes, such as carbonic anhydrase (CA), changes the water status, making it difficult to diagnose water deficit using leaf water potential (ψL) or stomatal conductance (gs).
Deke Xing, Xiaojian Xu, Yanyou Wu, Yujing Liu, Yansheng Wu, Jiheng Ni, Ahmad Azeem   +6 more
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Water status diagnosis in greenhouse drip-irrigated tomato and celery using leaf turgor dynamics and machine learning

Frontiers in Plant Science
IntroductionAccurate crop water status monitoring is crucial for optimized irrigation in controlled environments, but traditional approaches relying on damaging measurements or sporadic sampling frequently restrict real-time evaluation.MethodsThis study ...
Quanyue Xu, Quanyue Xu, Ruixia Chen, Ruixia Chen, Xufeng Li, Xufeng Li, Hongxiang Wu, Hongxiang Wu, Juanjuan Ma, Juanjuan Ma, Lijian Zheng, Lijian Zheng   +11 more
doaj   +1 more source

Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae

FEBS Open Bio, EarlyView.
Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj, Eline M. F. de Lange, Klaas A. Sjollema, Ben N. G. Giepmans   +3 more
wiley   +1 more source

Effects of Anti-hail Net Transmittance and Installation System on Grapevine (Vitis vinifera L. cv. Malbec) Canopy Microclimate and Water Status

Revista de la Facultad de Ciencias Agrarias
Hailstorms cause substantial economic loss in vineyards worldwide by reducing yield and deteriorating grape quality. Although anti-hail nets are extensively used to prevent hail damage, their effects on canopy microclimate, vine water status ...
Cesar Gabriel Nahuel, Martín Fanzone, Carina V. González, Jorge Perez Peña, Pablo Castro, Jorge Alejandro Prieto   +5 more
doaj  

Mid-Season Yield Estimation in High-Productivity Vineyards: A Preliminary Modeling Framework for Free-Canopy Systems

Agronomy
Accurate vineyard yield estimation is essential for harvest planning, resource allocation, and economic decision-making, particularly under conditions of high spatial variability.
César Acevedo-Opazo, Paulo Cañete-Salinas, Miguel Araya-Alman, Cristian Ackerknecht-Espinosa, Lucas Vásquez, Yerko Moreno-Simunovic   +5 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source