Results 51 to 60 of about 279,366 (305)

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

The priority of the gospel: church planting in the church of England examined in the light of Anglican tradition and the ministry of the apostle Paul [PDF]

open access: yes, 1997
Church planting, the establishing of new churches, is a significant feature of the modern Church of England, but has received little theological and historical analysis.
Dunthorne, Paul
core  

Elevation-induced changes in soil sulfur availability in tea plantations

open access: yesFrontiers in Plant Science
Chinese tea plantations, as the world’s leading tea producers, face escalating challenges such as soil acidification and nutrient management. Investigating soil nutrient variations along elevation gradients is crucial.
Hong Wang   +7 more
doaj   +1 more source

Forest Regeneration and Forest Restoration Research in Latvia

open access: yesAkadēmiskā Dzīve, 2019
The forest has always been important for Latvian residents, as a shelter, as a home, as a source of resources, as well as a place for recreation and a place of adoration. Forest is a main supplier of raw materials to the economy a source of wood and non-
Dagnija Lazdiņa
doaj   +1 more source

KAJIAN KELAYAKAN PENGOLAHAN MEDIA TANAM ORGANIK PERUSAHAAN PERORANGAN “2 TIA AGRI” DI KALIMANTAN SELATAN

open access: yesZiraa'ah: Majalah Ilmiah Pertanian, 2022
This study aims to determine technically the implementation of organic growing media processing business on PO. 2 Tia Agri. To find out economically the large costs, revenues, profits and business feasibility of processing organic growing media on PO.
Husinsyah Husinsyah, Fitri Mahyudi
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Combined drought and high temperature stress enhances saikosaponin biosynthesis in Bupleurum Chinense through multi-level regulatory mechanisms

open access: yesBMC Plant Biology
Background As an important medicinal plant, the synthesis of active ingredient saikosaponin in Bupleurum chinense DC. is significantly influenced by environmental factor stress.
Linlin Yang   +8 more
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

open access: yesFEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass   +2 more
wiley   +1 more source

Impact of climate change on the distribution of Ligustrum leucanthum using MaxEnt modeling

open access: yesScientific Reports
Anthropogenic climate change has hastened habitat loss and fragmentation for wild animals and vegetation. However, the absence of sufficient and trustworthy information on their geographical distribution has impeded effective conservation management ...
Guiquan Song   +7 more
doaj   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

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