Results 51 to 60 of about 9,437,590 (297)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Emerging experimental and computational methods for studying redox‐regulated structural transitions
FEBS Letters, EarlyView.Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass +2 more
wiley +1 more source
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
“Planting Trees is Always Good” [PDF]
, 2020 This thesis explores how two Swedish companies and a sample of Swedish consumers describe the role of private actors in climate change mitigation. Carbon offsetting by planting trees in the Global South has become a common approach for Swedish food and ...
Planting Mollaoglu, Emil
core +1 more source
Influence of planting designs on winter thermal comfort in an urban park
Journal of Environmental Engineering and Landscape Management, 2018 Various planting designs behave in different ways on microclimate and thermal comfort due to mainly distinct features of vegetation type and ratio. The papers simulated the microclimate behavior and thermal comfort of different planting design scenarios ...
Nima Karimi Afshar +3 more
doaj +1 more source
Chiral separation of chloroalkanes with the chromatographic column onboard Martian rovers
FEBS Letters, EarlyView.Computer image of the Rosalind Franklin Rover of ESA's ExoMars mission. ExoMars is scheduled to land on planet Mars in Oxia Planum in 2029. This area represents an interesting spot to look for biosignatures. Investigations of ExoMars include measurement on molecular chirality. We show that chiral chloroalkanes, that have been identified on Mars, can be
Asma Merzougui +4 more
wiley +1 more source
A new design approach for Süleyman Demirel University Botanical Garden
Turkish Journal of Forestry, 2019 Botanical gardens were first established only for scientific reasons, however, later they have been started to be used for educational and recreation reasons.
Şirin DÖNMEZ +2 more
doaj +1 more source
Planting Design Approach in Sustainable Urban Planning
International Journal of Built Environment and Sustainability, 2021 The increased pressures associated with climate change and urbanization processes adversely affect the quality of life of the cities and damage the sustainability of the cities.
Demet Ulku Gulpınar Sekban +1 more
doaj +1 more source
Determinant moments for the design management occurrence in fashion industry [PDF]
, 2018 Design management has occupied a privileged place in debates related to the field of design and innovation in fashion industry. The apparel industry, in particular, presents a dynamic character, requiring constant updates on raw materials, changes in ...
Libânio, Cláudia de Souza +5 more
core +1 more source