Results 41 to 50 of about 67,841 (303)
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
MONTANE SOUTH AFRICAN GRASSLANDS AS A NEW PLANTING DESIGN FORM IN URBAN GREENSPACE [PDF]
, 2013 The aims of this study were to develop communities of South African montane grassland species as a new planting design form in urban parks and green spaces.
Sayuti, Zulhazmi
core
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
The Design of Victoria Community Park, Victoria, VA
, 2023 The Community Design Assistance Center (CDAC) was hired by the Town of Victoria, to develop a conceptual master plan, planting plan, and cost estimates for the design of a community park.
Schooley, Chris +2 more
core
Influence of planting designs on winter thermal comfort in an urban park
Journal of Environmental Engineering and Landscape Management, 2018 Various planting designs behave in different ways on microclimate and thermal comfort due to mainly distinct features of vegetation type and ratio. The papers simulated the microclimate behavior and thermal comfort of different planting design scenarios ...
Nima Karimi Afshar +3 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
A new design approach for Süleyman Demirel University Botanical Garden
Turkish Journal of Forestry, 2019 Botanical gardens were first established only for scientific reasons, however, later they have been started to be used for educational and recreation reasons.
Şirin DÖNMEZ +2 more
doaj +1 more source
Planting Design Approach in Sustainable Urban Planning
International Journal of Built Environment and Sustainability, 2021 The increased pressures associated with climate change and urbanization processes adversely affect the quality of life of the cities and damage the sustainability of the cities.
Demet Ulku Gulpınar Sekban +1 more
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source