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Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu+17 more
wiley +1 more source
Three‐dimensional (3D) biological systems have become key tools in lymphoma research, offering reliable in vitro and ex vivo platforms to explore pathogenesis and support precision medicine. This review highlights current 3D non‐Hodgkin lymphoma models, detailing their features, advantages, and limitations, and provides a broad perspective on future ...
Carla Faria+3 more
wiley +1 more source
Evaluating Plant Brushing as a Strategy for Height Control in Edible Crop Species [PDF]
Greenhouse growers producing edible crops can encounter specific challenges when optimizing growing conditions. One challenge is soft growth associated with rapid tissue expansion. Soft growth can lead to plants falling over or soft, floppy leaves. These
Birnstihl, Dan
core +1 more source
A change in temperature modulates defence to yellow (stripe) rust in wheat line UC1041 independently of resistance gene Yr36 [PDF]
Background Rust diseases are of major importance in wheat production worldwide. With the constant evolution of new rust strains and their adaptation to higher temperatures, consistent and durable disease resistance is a key challenge.
Alice R Mitchell+8 more
core +1 more source
From omics to AI—mapping the pathogenic pathways in type 2 diabetes
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan+2 more
wiley +1 more source
Are plants with anti-cancer activity resistant to crown gall? : A test of hypothesis [PDF]
The Crown gall tumour assay (CGTA) is one of several bench top bioassays recommended for the rapid screening of plants with anti-cancer activity. The rationale for the use of the bioassay is that the tumorogenic mechanism initiated in plant tissues by ...
BT. Ramesha+4 more
core +1 more source
Plant succession; an analysis of the development of vegetation, [PDF]
Frederic E. Clements
openalex +1 more source
The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson+7 more
wiley +1 more source
Design of PID Controllers Satisfying Gain Margin and Sensitivity Constraints on a Set of Plants [PDF]
This paper presents a method for the design of PID-type controllers, including those augmented by a filter on the D element, satisfying a required gain margin and an upper bound on the (complementary) sensitivity for a finite set of plants.
Nagurka, Mark L., Yaniv, O.
core +1 more source