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Atherosclerotic Plaque Healing. [PDF]

New England Journal of Medicine, 2020
Atherosclerotic Plaque Healing Atherosclerotic plaque rupture and erosion result in acute coronary syndromes. Plaque healing after initial disruption has been less extensively studied.
R. Vergallo, F. Crea
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CD47‐ and Integrin α4/β1‐Comodified‐Macrophage‐Membrane‐Coated Nanoparticles Enable Delivery of Colchicine to Atherosclerotic Plaque

Advanced Healthcare Materials, 2021
Atherosclerosis is a chronic inflammatory disease and the major pathological factor of most cardiovascular diseases, leading to ≈1/3 of deaths worldwide.
Yuyu Li, Junyi Che, Lei Chang, Meng Guo, Xue Bao, Dan Mu, Xuan Sun, Xin Zhang, Wen-Liang Lu, Jun Xie   +9 more
semanticscholar   +1 more source

Imaging of atherosclerotic plaque

The International Journal of Cardiovascular Imaging, 2004
The behavior and composition of coronary atherosclerotic plaques are ultimately responsible for the threat of acute ischemic events in patients with coronary artery disease. Different imaging modalities have been developed over the last several years in order to better characterize the atherosclerotic plaque and attempt to predict those in peril of ...
Dominick J. Angiolillo, Marco A. Costa, Mario A. Pulido   +2 more
openaire   +3 more sources

Atherosclerotic plaque development

The International Journal of Biochemistry & Cell Biology, 2009
Atherosclerosis is now recognized as an inflammatory/immunomodulatory reaction to the presence of oxidized low-density lipoproteins within the arterial wall, often times in the setting of such risk factors as family history, hypercholesterolemia, high blood pressure, diabetes mellitus and smoking.
Quang T. Bui, Robert L. Wilensky, Maxwell Prempeh   +2 more
openaire   +3 more sources

Devouring atherosclerotic plaques

Nature Nanotechnology, 2020
Targeting of local macrophages by functionalized carbon nanotubes enables efferocytosis and clearance of atherosclerotic plaques.
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The Atherosclerotic Plaque

2009
Even though coronary, cerebral, and peripheral arterial disease represents the most common features of atherosclerosis, it progresses in the absence of any symptoms for most of its developmental course. Generally, the severity of a coronary stenosis is of poor predictive value for cardiac events such as sudden death, myocardial infarction, or unstable ...
Massimo Fioranelli, Maddalena Piro, Sara di Michele   +2 more
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Taking AIM2 at atherosclerotic plaques

Nature Reviews Drug Discovery, 2021
Clonal haematopoiesis — an expansion of blood cell clones due to advantageous somatic mutations — is linked to myocardial infarction. A new study shows that activation of the AIM2 inflammasome in clonally expanded macrophages exacerbates atherosclerosis by driving both proliferation and pyroptosis.
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Development of atherosclerotic plaques

Acta Medica Scandinavica, 1985
ABSTRACT. Atherosclerosis is a multifactorial disease. A unified model for the lesion development reveals many connections between the response‐to‐injury hypothesis and the lipid hypothesis. Various cellular uptake mechanisms for native and modified lipoproteins are discussed with respect to foam cell formation and lesion development.
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Apoptosis in human atherosclerotic plaques

Apoptosis, 1999
Intimal cell death has been a recognized feature of advanced atherosclerotic disease. With the advent of DNA in situ end labelling and/or ultrastructural techniques, recent findings suggest that cells of an atheroma undergo programmed cell death or apoptosis. The pathophysiologic relevance of apoptosis in atherosclerotic disease is debatable. Apoptotic
Renu Virmani, Frank D. Kolodgie, Jagat Narula, P. Guillo   +3 more
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