Results 181 to 190 of about 1,105,082 (410)
Advanced Science, EarlyView.In the context of chronic hyperglycemia, a DDR is initiated, leading to the pathological activation of DNA‐PKcs in the diabetic heart. This activated DNA‐PKcs directly interacts with and phosphorylates YAP1 at Thr226, thereby increasing the nuclear expression of YAP1.
Junyan Wang +10 more
wiley +1 more source
Report a Case of Beauty Regeneration in a Child with Premature Tooth Decay
Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul, 2019 BACKGROUND AND OBJECTIVE: One of the biggest challenges in pediatric dentistry is the oral rehabilitation of children who have lost their teeth due to early childhood decay severe trauma.
D Alinejhad, N Amrollahi
doaj
Beitrag zur Kenntnis der Fischerschen Plaques im Gehirn und ihrer klinischen Bedeutung [PDF]
, 1911 George E. Schröder
openalex +1 more source
Simvastatin and Plaque Inflammation
Journal of the American College of Cardiology, 2007 We read with great interest the study by Tahara et al. ([1][1]) published recently in the Journal and concerned with tracking statin-induced inflammation reduction in atherosclerotic plaques using fluorodeoxyglucose positron emission tomography (FDG-PET).
James H.F. Rudd +2 more
openaire +3 more sources
Dynein‐Dependent Endo‐Lysosomal Degradation Drives Lewy Body Disorders Accompanied by Aβ Pathology
Advanced Science, EarlyView.This study investigates the impact of Aβ plaques on α‐synuclein (αSyn) pathologies in dementia with Lewy bodies (DLB). Co‐culturing primary neurons with AD mouse brain slices reveals impaired dynein‐dependent organelle trafficking, affecting αSyn degradation. Activating Rab7 restores this process, reducing αSyn inclusions.
Linlin Zhou +14 more
wiley +1 more source
Contribution à l'étude de l'équilibre élastique d'une plaque rectangulaire mince [PDF]
, 1900 E. Estanave
openalex +1 more source
Listerin Alleviates Alzheimer's Disease through IRE1‐mediated Decay of TLR4 mRNA
Advanced Science, EarlyView.Alzheimer's disease (AD) progression is influenced by microglia‐mediated neuroinflammation. Here, it is demonstrated that Listerin suppresses neuroinflammatory signaling and cognitive impairment in AD models by triggering IRE1α‐mediated TLR4 mRNA decay. Adenoviral Listerin delivery reduces amyloid‐β pathology, positioning it as a new therapeutic target.
Fei Qin +9 more
wiley +1 more source
Incorporating Interstellar Communication into the Classroom: The Pioneer 10 Plaque [PDF]
, 2020 The Pioneer 10 plaque was the first purposeful interstellar message designed to contact extraterrestrial life. Contained within the simple pictorial message are elements that indicate humankind\u27s location in the Milky Way galaxy, who sent the message,
Petrunia, Matthew
core +1 more source
Apoptotic Bodies Restore NAD and Mitochondrial Homeostasis in Fibroblasts
Advanced Science, EarlyView.Mesenchymal stem cell‐derived apoptotic bodies (MSC‐ABs) target keloid fibroblasts (KFs), restoring nicotinamide adenine dinucleotide (NAD) metabolism and mitochondrial function, suppressing collagen overproduction, and rebalancing tissue homeostasis, offering a novel therapy for keloid.
Shutong Qian +10 more
wiley +1 more source