Results 211 to 220 of about 485,848 (308)

Prognostic value of AI-enabled quantitative coronary CT angiography for major adverse cardiovascular events: A systematic review and meta-analysis. [PDF]

Int J Cardiol Cardiovasc Risk Prev
Malik M, Batista P, Lucena LA, Montenegro MV, Santos Silva RRA, Fischer-Bacca CO, Giorgi J, Strom J.   +7 more
europepmc   +1 more source

Shared Metabolic–Proteinopathy Axis in Alzheimer's Disease and Parkinson's Disease: Evidence for a Convergent but Not Identical Disease Spectrum

AGING MEDICINE, EarlyView.
This review explores the common pathological mechanisms underlying Alzheimer's disease (AD) and Parkinson's disease (PD), with an emphasis on glucose metabolism and insulin resistance. We examine how disruptions in glucose metabolism and insulin resistance influence the onset and advancement of both Alzheimer's disease (AD) and Parkinson's disease (PD).
Shun‐yu Yao, Miao‐qiao Du, Lan‐xin Lin, Xu‐hui Kang, Dai‐yi Jiang, Yong Peng   +5 more
wiley   +1 more source

Amyloid exacerbates tau and alpha-synuclein pathologies, behavioral impairments, and neuroinflammation in a mixed dementia model. [PDF]

Alzheimers Dement
Rabichow BE, Nixon L, Tallant LE, Gibson KA, Nascari DG, Barnett JH, Massa N, Fryer JD.   +7 more
europepmc   +1 more source

Qualitative Plaque Stabilization But Not Quantitative Plaque Regression

Circulation Journal, 2012
openaire   +3 more sources

Spatially Informed Feature Selection and Machine Learning in Matrix‐Assisted Laser Desorption/Ionization Imaging for Cohort‐Scale Molecular Tissue Phenomics in Glioblastoma

Advanced Intelligent Discovery, EarlyView.
Matrix‐assisted laser desorption/ionization imaging‐based identification of reliable small molecule markers across heterogeneous glioblastoma cohorts is challenging with intensity‐only methods. We present spatially informed feature selection (SIFS), a spatially informed framework that prioritizes molecules consistently colocalizing with histopathology.
Shad A. Mohammed, Denis Abu Sammour, Dirk C. Hoffmann, Philipp Sievers, Tobias Bausbacher, Melissa Hahn, Yasemin Ucal, Iris Mildenberger, Christiane A. Opitz, Stefan Schmidt, Michael Platten, Oliver Wasenmüller, Wolfgang Wick, Andreas von Deimling, Tobias Kessler, Carsten Hopf   +15 more
wiley   +1 more source

Retrieval of an atherosclerotic plaque-vessel wall complex during mechanical thrombectomy: illustrative case. [PDF]

J Neurosurg Case Lessons
Yoshida S, Ikeda H, Akaike N, Uezato M, Wada M, Kinosada M, Kurosaki Y, Chin M.   +7 more
europepmc   +1 more source

A Novel NR3C1 Frameshift Variant Associated With Familial Glucocorticoid Resistance Syndrome: An Integrated Analysis of Steroid Profiling and Structural Modeling

American Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Glucocorticoid resistance syndrome (GRS) is a rare hereditary disorder caused by pathogenic variants in NR3C1, characterized by marked phenotypic heterogeneity and frequent misdiagnosis as primary aldosteronism or subclinical Cushing's syndrome.
Sufang Yun, Zhifeng Zhu, Fengye Zhou, Ying Liu, Chunfang Liang, Haitao Ju, Lin Lu, Zhaoli Yan   +7 more
wiley   +1 more source

Spectral computed tomography characterization of coronary atherosclerotic plaque: principles, imaging biomarkers, and clinical significance. [PDF]

Front Cardiovasc Med
Liu Y, Peng Y, Wu H, Li Y.
europepmc   +1 more source

The liver‐brain axis: A multidimensional regulatory network implicated in Alzheimer's disease pathogenesis and clinical implications

Animal Models and Experimental Medicine, EarlyView.
Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley   +1 more source

Mex-3 RNA-binding family member A limits macrophage ferroptosis-associated injury linked to the SLC7A11/GPX4 pathway in diabetic atherosclerosis. [PDF]

Clin Transl Med
Ma Y, Liu J, Xing Y, Pan S, Annayev BH, Wu W, Wang X, Liu Z.   +7 more
europepmc   +1 more source