Animal Models and Experimental Medicine, EarlyView.Schematic diagram of the core pathways of the liver‐brain axis in regulating AD. The liver regulates cerebral Aβ deposition, tau phosphorylation, and neuroinflammation through pathways such as metabolic detoxification (urea cycle, ketone body metabolism, glutathione antioxidant system), molecular secretion (APOE, CRP, FGF21, IGF‐1), and Aβ clearance ...
Ning Zhang, Wei Chen, Meng Wang
wiley +1 more source
Refining a preclinical model of viral myocarditis in accordance with biotech standards
Animal Models and Experimental Medicine, EarlyView.This study aimed to refine a murine model of Coxsackievirus B3‐induced myocarditis by integrating dietary and imaging innovations to improve animal welfare, data quality, and clinical applicability. The refined diet significantly reduced animal health burden, reduced weight loss, and stabilized blood glucose during development of cardiac inflammation ...
Jonas Stewen +9 more
wiley +1 more source
Integrating Lateral Super-Resolution and Axial Progression Reveals Distinct Clathrin Pit Formation Pathways. [PDF]
TrafficThompson C +3 more
europepmc +1 more source
Perivascular Spaces as Determinants of Amyloid, Tau, and Vascular Biomarker Progression
Annals of Neurology, EarlyView.Objective Magnetic resonance imaging (MRI)‐visible enlarged perivascular spaces (PVS) are markers of cerebral small vessel disease (SVD) and aging, processes implicated in both neurodegenerative and cerebrovascular pathologies. However, longitudinal positron emission tomography (PET) studies examining PVS as a mechanism underlying Alzheimer's disease ...
Audrey Low +11 more
wiley +1 more source
Angewandte Chemie, EarlyView.Dehydroamino acids (DHAA) are atypical electrophilic sites that lead to crosslinked proteins in Alzheimer's disease (AD) brains. No catalyst for their formation has been known in humans. We report that metal oxides catalyze β‐elimination of phosphoserine and phosphothreonine in model peptides at pH 7.5°C and 37°C, yielding DHAAs.
Samuel W. Markovich +3 more
wiley +2 more sources
Impact of a Multi-Component Preventive Oral Health Program on Dental Plaque Scores for Individuals with Special Health Care Needs. [PDF]
Clin Cosmet Investig DentAlrazooq WS, Alhurishi SA, Shah AH.
europepmc +1 more source
Distribution of Big Tau Isoforms in the Human Central and Peripheral Nervous System
Annals of Neurology, EarlyView.Objective Tau is widely studied in neurodegeneration, yet most work has focused on canonical brain tau isoforms. A longer isoform, “big tau,” produced by inclusion of exon 4a, is expressed in the peripheral nervous system (PNS) and central nervous system (CNS) regions.
Rama Krishna Koppisetti +17 more
wiley +1 more source
Investigation of the Additional Use of a Single‑tufted Brush with a Standard Manual Toothbrush in Dental Students. [PDF]
Oral Health Prev DentMuhterem A +5 more
europepmc +1 more source
Modified Titanium Dental Implants: The Current Progress of Soft‐Tissue Integration Methods
Advanced NanoBiomed Research, EarlyView.Dental implants are an established solution for tooth loss, yet achieving soft tissue integration (STI) around the transmucosal region remains a challenge. The natural tooth–gingiva interface is poorly replicated on titanium implants. This review explores surface modification strategies, ranging from surface chemistry and topography to biological ...
Daniel De Maria +5 more
wiley +1 more source
Evaluation of D&C Red No. 33 as an alternative to erythrosine for plaque disclosure: a randomized crossover trial. [PDF]
BMC Oral HealthSooampon S +4 more
europepmc +1 more source