Results 31 to 40 of about 117,541 (261)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Vascular normalization confers an endothelial immune suppressive gene expression profile

Molecular Oncology, EarlyView.
We compare the immunoregulatory gene expression profiles of healthy endothelial cells or endothelial cells from tumors having a normalized endothelium (low leakage) with that of wild‐type tumors (high leakage) and observe that the wild‐type tumor endothelium exhibits immunostimulatory properties.
Liqun He, Michael Welsh
wiley   +1 more source

Effectiveness of raw robusta coffee bean solution and coffee instant robusta to plaque

Padjadjaran Journal of Dentistry, 2014
Introduction: It is known that coffee bean consists of higher tannin and trigonelin than instant. Those substances have a role to hamper plaque formation by preventing bacteria sticking on peliccle. The study was conducted to find out the efectiveness of
Adila Muchlisha, Nunung Rusminah, Emma Rachmawati   +2 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Investigation of the inter-rater reliability of three different plaque indices used in patients with fixed orthodontic appliances.

PLoS ONE
Background/objectivesTo analyze the inter-rater reliability of three different plaque indices with regard to raters' orthodontic experience.Materials/methodsThe study analyzed 50 photographs of patients with maxillary and mandibular multibracket ...
Christina Erbe, Teresa Temming, Daniela Ohlendorf, Irene Schmidtmann, Priscila Ferrari-Peron, Ambili Mundethu, Heinrich Wehrbein   +6 more
doaj   +1 more source

EFEKTIVITAS BERKUMUR TEH HITAM TERHADAP PENURUNAN AKUMULASI PLAK PADA ANAK USIA 7-8 TAHUN

ODONTO: Dental Journal, 2018
Background: Black tea (Camellia sinensis) mouthwash is type of tea that Indonesian usually consume. Black tea contains substances which prevent caries by obstructing plaque formation.
Prastiwi Setianingtyas, Lisa Prihastari, Nurul Wardhani   +2 more
doaj   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Correlation of Parental and Child Dental Plaque Levels: A Clinical Study

Applied Sciences
Objective: This clinical study aimed to explore the correlation between dental plaque levels in parents and their children. Specifically, the study examined differences in plaque correlation between mother–child and father–child pairs and evaluated the ...
Sergio Mazzoleni, Andrea Zuccon, Sara De Matteo, Roberta Gaia Parcianello, Riccardo Favero, Riccardo Ludovichetti, Giulia Malvicini, Francesco Saverio Ludovichetti   +7 more
doaj   +1 more source

Association Between Motor Pathway Damage and Motor Deficit in Upper and Lower Limb in People With MS

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Corticospinal tract damage is common in people with MS, but the degree of clinical symptoms varies. We hypothesize that corticospinal tract lesions are more extensive and severe in people with MS with motor impairments in both upper and lower limbs.
Mathilde Liffran, Malo Gaubert, Alice Dufey, Elise Bannier, Audrey Rico, Jean‐Christophe Ferré, Raphaël Chouteau, Laure Michel, Emmanuelle Le Page, Virginie Callot, Bertrand Audoin, Sarah Demortière, Benoît Combès, Anne Kerbrat   +13 more
wiley   +1 more source