Results 91 to 100 of about 700,142 (373)

Functional Materials Targeted Regulation of Gasdermins: From Fundamentals to Functionalities and Applications

Advanced Science, EarlyView.
Targeted regulation of pyroptosis to modulate the immune landscape is a novel design strategy for cancer immunotherapy and anti‐inflammatory treatment. Pyroptosis, as a double‐edged sword, underscores the importance of optimizing the design strategy of functional materials and appropriately activating pyroptosis for the effective treatment of diseases.
Luyao Tian, Shuo Piao, Xia Li, Lanping Guo, Luqi Huang, Wenyuan Gao   +5 more
wiley   +1 more source

Atherosclerotic plaque features relevant to rupture-risk detected by clinical photon-counting CT ex vivo: a proof-of-concept study

European Radiology Experimental
Background To identify subjects with rupture-prone atherosclerotic plaques before thrombotic events occur is an unmet clinical need. Thus, this proof-of-concept study aims to determine which rupture-prone plaque features can be detected using clinically ...
Annelie Shami, Jiangming Sun, Chrysostomi Gialeli, Hanna Markstad, Andreas Edsfeldt, Marie-Louise Aurumskjöld, Isabel Gonçalves   +6 more
doaj   +1 more source

Semantic decomposition Network with Contrastive and Structural Constraints for Dental Plaque Segmentation [PDF]

arXiv, 2022
Segmenting dental plaque from images of medical reagent staining provides valuable information for diagnosis and the determination of follow-up treatment plan. However, accurate dental plaque segmentation is a challenging task that requires identifying teeth and dental plaque subjected to semantic-blur regions (i.e., confused boundaries in border ...
arxiv  

MRI of Atherothrombosis Associated With Plaque Rupture [PDF]

Arteriosclerosis, Thrombosis, and Vascular Biology, 2005
Objective— MRI would be a valuable noninvasive diagnostic tool to study plaque-associated thrombi. We defined the imaging characteristics of these thrombi, composed primarily of platelets and fibrin, and distinguished them clearly from the vessel lumen and underlying atherosclerotic plaque in an ...
Jason Viereck, Ye Qiao, Frederick L. Ruberg, Michael T. Johnstone, Kara Y. Detwiller, James A. Hamilton, Alexandra S. Perez   +6 more
openaire   +3 more sources

Mechanical Biomimetic Nanocomposites for Multidimensional Treatment of Arterial Thrombosis

Advanced Science, EarlyView.
In this study, a mechanical biomimetic nanocomposite is developed, guided by photoacoustic imaging, to achieve highly efficient and safe thrombolysis through the synergistic effects of photothermal therapy and pharmacological intervention. Most notably, the nanoparticle improves the microenvironment of arterial thrombi, marked by high shear stress and ...
Ying Li, Qi Xiang, Yan Zhang, Fuxue Luo, Yunfang Wu, Haitao Ran, Yang Cao   +6 more
wiley   +1 more source

New insights into fibrous cap thickness of vulnerable plaques assessed by optical coherence tomography

BMC Cardiovascular Disorders, 2022
Objective Vulnerable plaques with fibrous cap thickness (FCT) of ≤65 μm are prone to rupture and/or thrombosis. However, plaques with FCT > 65 μm cause acute myocardial infarction and even sudden death. We aimed to investigate the relationship between 65 
Xianglan Liu, Wujian He, Xulin Hong, Duanbin Li, Zhezhe Chen, Yao Wang, Zhaoyang Chen, Yi Luan, Wenbin Zhang   +8 more
doaj   +1 more source

Macrophage WEE1 Directly Binds to and Phosphorylates NF‐κB p65 Subunit to Induce Inflammatory Response and Drive Atherosclerosis

Advanced Science, EarlyView.
The present study shows that macrophage WEE1 drives NF‐κB activation and inflammatory atherosclerosis by directly phosphorylating p65 at S536. This finding illustrates a macrophage‐specific WEE1‐p65 axis in regulating inflammatory atherosclerosis and points out new directions to broaden the clinical applications for WEE1 inhibitors in atherosclerosis ...
Zhuqi Huang, Sirui Shen, Weixin Li, Mengyang Wang, Yudie Yang, Wu Luo, Xue Han, Zheng Xu, Julian Min, Xiaohong Long, Weijian Huang, Gaojun Wu, Yi Wang, Guang Liang   +13 more
wiley   +1 more source

Vulnerable Plaque in Patients with Acute Coronary Syndrome: Identification, Importance, and Management

US Cardiology Review, 2022
MI is a leading cause of morbidity and mortality worldwide. Coronary artery thrombosis is the final pathologic feature of the most cases of acute MI primarily caused by atherosclerotic coronary artery disease. The concept of vulnerable plaque has evolved
Atsushi Sakamoto, Anne Cornelissen, Yu Sato, Masayuki Mori, Rika Kawakami, Kenji Kawai, Saikat Kumar B Ghosh, Weili Xu, Biniyam G Abebe, Armelle Dikongue, Frank D Kolodgie, Renu Virmani, Aloke V Finn   +12 more
doaj   +1 more source

Acute Loss of miR-221 and miR-222 in the Atherosclerotic Plaque Shoulder Accompanies Plaque Rupture

Stroke, 2015
Background and Purpose— Atherosclerotic plaque vulnerability is accompanied by changes in the molecular and cellular function in the plaque shoulder, including a decrease in vascular smooth muscle cell proliferation.
Hernan A. Bazan, Samuel A. Hatfield, Chasity B. O’Malley, A. Brooks, Daniel J. Lightell, T. Cooper Woods   +5 more
semanticscholar   +1 more source

Astaxanthin ameliorates benzalkonium chloride–induced dry eye disease through suppressing inflammation and oxidative stress via Keap1‐Nrf2/HO‐1 signaling pathways

Animal Models and Experimental Medicine, EarlyView.
The flowchart of this research. Abstract Background Dry eye disease (DED) predominantly results from elevated tear film osmolarity, which can not only cause ocular inconvenience but may lead to visual impairments, severely compromising patient well‐being and exerting substantial economic burdens as well.
Ziyu Liu, Yaqiong Li, Jiayu Bao, Siyuan Li, Ya Wen, Peng Zhang, Jun Feng, Yinghui Wang, Lei Tian, Ying Jie   +9 more
wiley   +1 more source