Results 121 to 130 of about 755,810 (388)

Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden death

European Heart Journal, 2014
Our study underscores the importance of elastin fragmentation in the vessel wall as an accelerator of atherosclerosis with enhanced inflammation and increased neovascularization, thereby promoting the development of unstable plaques that eventually may ...
C. Van der Donckt, Jozef L. Van Herck, D. Schrijvers, G. Vanhoutte, M. Verhoye, I. Blockx, A. Van der Linden, D. Bauters, H. Lijnen, J. Sluimer, L. Roth, C. V. Van Hove, P. Fransen, M. Knaapen, Anne-Sophie Hervent, G. D. De Keulenaer, H. Bult, W. Martinet, A. Herman, G. D. De Meyer   +19 more
semanticscholar   +1 more source

PP2Acα Deficiency in Vascular Smooth Muscle Cells Accelerates Aortic Aneurysm and Dissection by Regulating KLF4 Phosphorylation and Ubiquitination

Advanced Science, EarlyView.
Vascular smooth muscle cells (VSMCs)‐specific deficiency of PP2Acα exacerbates aortic aneurysm and dissection (AAD) by promoting phenotypic switching through AKT1‐mediated phosphorylation and stabilization of Kruppel‐like factor 4 (KLF4). Reduced PP2Acα enhances KLF4 ubiquitination resistance, suppressing VSMC contractile genes and accelerating aortic ...
Wei‐Peng Hu, Ze‐Yu Cai, Qing‐Le Li, Tao Zhang, Xiang‐Yu Chu, Chang Wang, Qing‐Yi Zhang, Rong Qi   +7 more
wiley   +1 more source

Natriuretic peptide receptor-C is up-regulated in the intima of advanced carotid artery atherosclerosis [PDF]

, 2016
OBJECTIVE: Natriuretic peptide receptor-C (NPR-C/NPR-3) is a cell surface protein involved in vascular remodelling that is up-regulated in atherosclerosis. NPR-C expression has not been well characterized in human carotid artery occlusive lesions.
Abendschein, Dana R, Detering, Lisa, Harring, Scott D, Liu, Yongjian, Lu, Dongsi, Vemuri, Chandu, Woodard, Pamela K, Zayed, Mohamed A   +7 more
core   +3 more sources

A MXene‐Based Nanothermal Knife Inhibits Aggresome‐Mediated Persister Formation for Preventing Dental Caries

Advanced Science, EarlyView.
Early childhood caries (ECC) involves cariogenic persisters that evade antimicrobial treatment. Persisters achieve this by downregulating heat shock proteins (HSPs) and formation of protein aggregates. Ti3C2 MXene‐based photothermal therapy (PTT) acts as a “nanothermal knife,” disrupting membranes, upregulating HSPs, inhibits aggregates, prevents ...
Yinyin Zhang, Leilei Yang, Jing jiao, Wenshuai Li, Sen Lin, Xianlong Zong, Haoyang Qin, Danfeng Liu, Rui Li   +8 more
wiley   +1 more source

The Use of Biomarkers for the Early Detection of Vulnerable Atherosclerotic Plaques and Vulnerable Patients. A Review

Journal of Cardiovascular Emergencies, 2016
Acute coronary syndromes represent the most severe consequences of atherosclerosis, most often triggered by the rupture of a coronary plaque, which, for various reasons, has become unstable.
Benedek Theodora, Maurovich-Horváth Pál, Ferdinandy Péter, Merkely Béla   +3 more
doaj   +1 more source

Local critical stress correlates better than global maximum stress with plaque morphological features linked to atherosclerotic plaque vulnerability: an in vivo multi-patient study

BioMedical Engineering OnLine, 2009
Background It is believed that mechanical stresses play an important role in atherosclerotic plaque rupture process and may be used for better plaque vulnerability assessment and rupture risk predictions. Image-based plaque models have been introduced in
Dong Li, Hatsukami Thomas S, Canton Gador, Teng Zhongzhao, Tang Dalin, Huang Xueying, Yuan Chun   +6 more
doaj   +1 more source

Simulation of deposit formation in particle laden flows: thermal properties [PDF]

, 2003
Fatty deposits formed on arterial walls lead to atherosclerosis but it is the interplay between these deposits and the vessel walls which governs the growth of plaque formation.
Buick, J.M., Collins, M.W., Cosgrove, J.A., Mulholland, A.J., Steves, B.A., Tonge, S.J.   +5 more
core   +1 more source

Ligilactobacillus Murinus and Lactobacillus Johnsonii Suppress Macrophage Pyroptosis in Atherosclerosis through Butyrate‐GPR109A‐GSDMD Axis

Advanced Science, EarlyView.
Oral aspirin administration induces intestinal expansion of Lactobacillus murinus and Lactobacillus johnsonii, which suppresses the progression of atherosclerosis. This microbial expansion significantly enhances butyrate production by providing lactate as a metabolic substrate, thereby fostering the growth of butyrate‐producing bacteria. Butyrate plays
Rui Hua, Ning Ding, Yiming Hua, Xiaoke Wang, Yu Xu, Xiangrui Qiao, Xue Shi, Ting Bai, Ying Xiong, Xiaozhen Zhuo, Chong Fan, Juan Zhou, Yue Wu, Junhui Liu, Zuyi Yuan, Ting Li   +15 more
wiley   +1 more source

Sonodynamic Therapy Suppresses Neovascularization in Atherosclerotic Plaques via Macrophage Apoptosis-Induced Endothelial Cell Apoptosis

JACC: Basic to Translational Science, 2020
Summary: During atherosclerosis plaque progression, pathological intraplaque angiogenesis leads to plaque rupture accompanied by thrombosis, which is probably the most important cause of arteries complications such as cerebral and myocardial infarction ...
Jianting Yao, MD, PhD, Weiwei Gao, MD, Yu Wang, MD, PhD, Lu Wang, PhD, Kamal Diabakte, MD, Jinyang Li, MD, Jiemei Yang, MD, Yongxing Jiang, MD, Yuerong Liu, MD, Shuyuan Guo, MD, Xuezhu Zhao, MD, Zhengyu Cao, MD, Xi Chen, MD, PhD, Qiannan Li, MD, Haiyu Zhang, PhD, Wei Wang, MD, Zhen Tian, PhD, Bicheng Li, MD, PhD, Fang Tian, MD, PhD, Guodong Wu, MD, Shirin Pourteymour, PhD, Xi Huang, MD, Fancheng Tan, MD, Xiaoru Cao, MD, Zhuowen Yang, MD, Kang Li, PhD, Yan Zhang, PhD, Yong Li, MD, PhD, Zhiguo Zhang, PhD, Hong Jin, MD, PhD, Ye Tian, MD, PhD   +30 more
doaj  

Nestinþ cells direct inflammatory cell migration in atherosclerosis [PDF]

, 2016
Atherosclerosis is a leading death cause. Endothelial and smooth muscle cells participate in atherogenesis, but it is unclear whether other mesenchymal cells contribute to this process. Bone marrow (BM) nestinþ cells cooperate with endothelial cells in
Andrés, Vicente, Chevre, Raphael, Martinez Gonzalez, José, Méndez Ferrer, Simón, Ordoñez, Antonio, Rodríguez, Cristina, Toro Estévez, Raquel del   +6 more
core