Results 121 to 130 of about 374,414 (247)

Animal models for plaque rupture: a biomechanical assessment

, 2016
Rupture of atherosclerotic plaques is the main cause of acute cardiovascular events. Animal models of plaque rupture are rare but essential for testing new imaging modalities to enable diagnosis of the patient at risk. Moreover, they enable the design of
Daemen, Mat J., Daemen, MJ, Hoogendoorn, Ayla, Gijsen, Frank J. H., van der Heiden, Kim, Gijsen, Frank   +5 more
core   +1 more source

Higher remnant cholesterol to lymphocyte ratio is associated with vulnerable plaque features in acute coronary syndrome

Frontiers in Cardiovascular Medicine
BackgroundRemnant cholesterol to lymphocyte ratio (RCLR) integrates atherogenic lipid metabolism and systemic inflammation, potentially reflecting plaque vulnerability in acute coronary syndrome (ACS).
Yingzheng Liu, Xuesong Liu, Weiren Yan, Ronglin Sun, Yao Yu, Aiming Chen, Zhenyu Dong, Xinsheng Li, Haichen Lv   +8 more
doaj   +1 more source

In Silico Clinical Trials in Drug Development: Virtual Patients, Applications, and Regulatory Convergence

Clinical Pharmacology &Therapeutics, EarlyView.
Conventional clinical trials remain the benchmark for evaluating therapeutic safety and efficacy, yet they are constrained by escalating costs, withdrawal over the extended follow‐up periods, recruitment difficulties, ethical limits, and a restricted ability to characterize heterogeneous populations.
Maximilian Balmus, Sheng‐Ya Wang, Edward W. G. Ashton, Rosie K. Barrows, Molly Monks, Yuzhang Ge, Arthur Lefebvre, Steven A. Niederer   +7 more
wiley   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Novel markers of plaque rupture in patients with chest pain

, 2017
Chest pain presentations to the accident and emergency department account for approximately 20% of admissions. Determining those patients at high risk of plaque rupture the squeal of which is ischemia and myocardial necrosis continues to be clinically ...
Amrit Bajrangee (7960910)
core   +1 more source

Mining Oral Probiotics Based on Their Pathogen Inhibition and Deodorization Roles

Food Bioengineering, EarlyView.
A promising oral probiotic strain Streptococcus salivarius MY‐6 stood out from 41 candidate lactic acid bacteria through the high‐throughput strategy based on its inhibitions of the growth and biofilm formation of the main oral pathogens Fusobacterium nucleatum and Porphyromonas gingivalis, as well as its elimination of oral malodor‐associated ...
Yaao Chen, Xiaofeng Xu, Yang Long, Deyi Yin, Haohao Sheng, Lei Du, Minxi Wan, Li Zhao, Jingli Xie   +8 more
wiley   +1 more source

Local atherosclerotic plaque composition and plaque rupture: An explorative study

, 2020
Introduction: Carotid atherosclerosis is characterized by the build-up of the so-called plaque tissue in the wall of the carotid artery. The rupture of carotid plaques can lead to acute manifestations, including ischemic stroke and transient ischaemic ...
Oversier, Rachel (author)
core  

Flexible wearable electronics for cardiovascular monitoring from surface signals to deep physiological insights

FlexMat, EarlyView.
This review organizes flexible wearable electronics for cardiovascular monitoring into four interconnected information layers: surface electrophysiology, hemodynamic sensing, vascular imaging, and biofluid biomarker analysis. This framework clarifies how electrical rhythm, vascular loading, structural and flow‐related features, and biochemical states ...
Qiao Chen, Hongwen Chen, Yuanyuan Li, Pingan Yang, Rui Li, Zhihao Zhou   +5 more
wiley   +1 more source

Pharmacological effects of gastrodin: Insight into neurological diseases and mechanism in ferroptosis and pyroptosis

Ibrain, Volume 11, Issue 1, Page 74-83, Spring 2025.
Pharmacological effects of gastrodin include prevention and treatment of cognitive decline and reperfusion injuries, anticonvulsion, antiepilepsy, antidepressants, and analgesia, which are related to antiferroptosis and antipyroptosis. Abstract Gastrodin, as an effective monomer of gastrodia elata, plays a significant role in anti‐inflammatory ...
Xue Zheng, Jing Li, Zhao‐Qiong Zhu
wiley   +1 more source

Assessment and management of dyspareunia in peri‐ and postmenopausal women: A phenotype‐based gynecologic approach

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Dyspareunia in peri‐ and postmenopausal women is common, clinically consequential, and often undertreated in gynecologic practice. Although genitourinary syndrome of menopause (GSM) is a frequent contributor, intercourse‐related pain may also reflect vestibular, pelvic floor, dermatologic, inflammatory, treatment‐related, and psychosocial ...
Marek Broul, Marcel Vančo, Jaroslava Banýrová, Aneta Hujová   +3 more
wiley   +1 more source