Results 211 to 220 of about 374,414 (247)

Plaque Rupture Model in Mice

2007
It is widely believed that rupture of a vulnerable atherosclerotic plaque leads to acute coronary events and stroke. However, the exact mechanisms involved in the plaque rupture remain unknown. Pathological animal models are valuable in the research on human disease mechanism, their therapy, and drug development.
Takeshi, Sasaki, Kae, Nakamura, Masafumi, Kuzuya   +2 more
openaire   +2 more sources

Models of plaque rupture

Drug Discovery Today: Disease Models, 2007
The most common underlying cause of the acute coronary syndromes is atherosclerotic plaque rupture, which is therefore of major clinical and pathological importance. Further insight into the aetiology of plaque rupture is essential to the development of new therapeutic strategies.
Christopher L. Jackson, Ulrike Benbow, Deborah J. Galley, Sharada Karanam   +3 more
openaire   +1 more source

Fatigue and plaque rupture in myocardial infarction

Journal of Biomechanics, 2006
Plaque rupture plays a role in the majority of acute coronary syndromes. Rupture has been associated with stress concentrations, which are affected by tissue properties and anatomy. In this study rupture was not approached as an acute syndrome, but rather as the culmination of a chronic injury or fatigue process. The aim of our study was to investigate
Antheunis, Versluis, Alan J, Bank, William H, Douglas   +2 more
openaire   +2 more sources

Proteinases and plaque rupture

Current Opinion in Lipidology, 2014
To review progress over the past 5 years in relating extracellular proteinases to plaque rupture, the cause of most myocardial infarctions, and consider the most promising prospects for developing related treatments.Cysteinyl cathepsins have been implicated in multiple macrophage functions that could promote plaque rupture. Cathepsin K is an attractive
openaire   +3 more sources

Local and Systemic Mechanisms of Plaque Rupture

Angiology, 2008
Mechanisms at the basis of coronary plaque instability are still elusive. On the one hand, accumulating data, from clinical and postmortem studies, suggest the role of systemic factors, in particular inflammation, in plaque rupture. On the other hand, local factors, in particular plaque composition, such as a large lipid-rich core and a thin fibrous ...
Luigi M, Biasucci, Milena, Leo, Gian Luigi, De Maria   +2 more
openaire   +2 more sources

PATHOPHYSIOLOGY AND INFLAMMATORY ASPECTS OF PLAQUE RUPTURE

Cardiology Clinics, 1996
Atherosclerotic plaque disruption with superimposed thrombosis is the main cause of acute coronary events. At present it is not known specifically how various risk factors influence the development and configuration of coronary plaques. The risk of plaque disruption depends more on plaque composition and vulnerability (plaque type) than on the degree ...
A P, Schroeder, E, Falk
openaire   +2 more sources

Numerical Simulation of Arterial Plaque Ruptures

International Journal of Material Forming, 2008
We present three-dimensional finite element simulations of damaged arteries, used to investigate the influence of the geometry and tissue properties on the plaque rupture. We adopt a baseline geometry reconstructed from a contiguous set of in vitro magnetic resonance images of a damaged artery.
FERRARA, ANNA, PANDOLFI, ANNA MARINA
openaire   +2 more sources

Cardiovascular Plaque Rupture

2002
Background and Pathophysiology Development of the Atherosclerotic Plaque Joan W. Berman, Marwan Kazimi, and Harry Ma Clinical and Pathological Correlates Renu Virmani, Allen P. Burke, Andrew Farb, and Frank D. Kolodgie The Role of Inflammation in Plaque Rupture Anton E. Becker and Allard C.
openaire   +1 more source

Atherosclerosis and plaque rupture

Catheterization and Cardiovascular Interventions, 2001
F G, Welt, D I, Simon
openaire   +2 more sources

Plaque Rupture, Compared With Plaque Erosion, Is Associated With a Higher Level of Pancoronary Inflammation.

JACC: Cardiovascular Imaging, 2022
Taishi Yonetsu, Hang Lee
exaly