Results 321 to 330 of about 755,810 (388)

Herpes simplex virus‐1 infection alters microtubule‐associated protein Tau splicing and promotes Tau pathology in neural models of Alzheimer's disease

Brain Pathology, Volume 35, Issue 5, September 2025.
HSV‐1 infection alters MAPT splicing and promotes Tau pathology in neural models of Alzheimer's disease. HSV‐1 infection in brain organoids and neuronal models increase 4R‐MAPT splicing and Tau hyperphosphorylation. HSV‐1 ICP27 is both necessary and sufficient for inducing these changes highlighting the potential role of HSV‐1 in Alzheimer's disease ...
Emmanuel C. Ijezie, Michael J. Miller, Celine Hardy, Ava R. Jarvis, Timothy F. Czajka, Lianna D'Brant, Natasha Rugenstein, Adam Waickman, Eain Murphy, David C. Butler   +9 more
wiley   +1 more source

Intravascular Tumour in a Dog Causing Skin Ulcerative Lesions

Veterinary Dermatology, EarlyView.
Alla Seleznova, Sohvi Blatter, Hugo Pereira, Ana Mafalda Lourenço, Iva Cvitas, Sara Soto   +5 more
wiley   +1 more source

Quantitative T1 is sensitive to cortical remyelination in multiple sclerosis: A postmortem MRI study

Brain Pathology, Volume 35, Issue 5, September 2025.
In a post‐mortem study using multiparametric qMRI of whole fixed human brains from people with multiple sclerosis (pwMS), we found evidence that quantitative T1 (qT1) is sensitive to remyelination in the cortex. In contrast, QSM and radial diffusivity were affected by cortical pathology independently of remyelination. Our data suggest that qT1 could be
Riccardo Galbusera, Matthias Weigel, Erik Bahn, Sabine Schaedelin, Alessandro Cagol, Po‐Jui Lu, Muhamed Barakovic, Lester Melie‐Garcia, Jonas Franz, Peter Dechent, Govind Nair, Ludwig Kappos, Wolfgang Brück, Christine Stadelmann, Cristina Granziera   +14 more
wiley   +1 more source

Arterial stiffness and atherosclerosis and incident cardiovascular events and all‐cause mortality in individuals with manifest cardiovascular disease with and without type 2 diabetes

Diabetic Medicine, Volume 42, Issue 9, September 2025.
Arterial stiffness and atherosclerosis and incident cardiovascular events and all‐cause mortality in individuals with manifest cardiovascular disease with and without type 2 diabetes. Abstract Background It is unclear if arterial stiffness and atherosclerosis are differentially related to cardiovascular events and mortality in individuals with manifest
Jan F. de Leijer, Frank L. J. Visseren, Birgitta K. Velthuis, Ynte M. Ruigrok, Jaco J.M. Zwanenburg, Manon G. van der Meer, Martin Teraa, Pim A. de Jong, Thomas T. van Sloten, on behalf of the UCC‐SMART study group   +9 more
wiley   +1 more source

High‐pressure freezing of mechanically stretched cells

Journal of Microscopy, Volume 299, Issue 3, Page 268-276, September 2025.
Abstract High‐pressure freezing (HPF) is an electron microscopy (EM) preparation technique with superb ultrastructural preservation. Combined with EM tomography it provides virtual EM serial sections with extraordinary spatial resolution. For HPF, cells are usually cultured on a rigid sapphire disc that provides a tight fit in the holding bracket of ...
Edward Felder, Jan L. Rüth, Bassam Abu‐Omar, Martin Wohlwend, Paul Walther, Clarissa Read   +5 more
wiley   +1 more source

Invasive Tracheal and Cranial Mediastinal Aspergillosis in a Young Otherwise Healthy Cat

Journal of Veterinary Internal Medicine, Volume 39, Issue 5, September/October 2025.
ABSTRACT A 3.5‐year‐old castrated male domestic medium hair cat was evaluated for dry cough and labored breathing. A cranial mediastinal mass was seen on thoracic radiographs. On computed tomography, the mass displaced the cranial vena cava and dorsally displaced and compressed the intrathoracic trachea.
Liliana M. Mutascio, J. Clifton Crooks
wiley   +1 more source

Studying the Role of Myenteric Amyloidosis in Gastrointestinal Dysmotility and Enteric Neural Dysfunction Using APP/PS1 Mice—Is It an Adequate Animal Model?

Neurogastroenterology &Motility, Volume 37, Issue 9, September 2025.
Amyloidosis in the central and enteric nervous system contributes to cognitive deficits and gastrointestinal dysmotility—the constipation in Alzheimer's disease (AD). APP/PS1 mice, a transgenic mouse model of amyloidosis, recapitulated the amyloidosis in the central nervous system; they were unsustainable in recapitulating the amyloidosis in the ...
Roxanne Fernandes, Marlene Masino, Emma Flood, Theresa A. Lansdell, Nikitha Srikrishna, Ryan Mui, Anne M. Dorrance, James J. Galligan, Hui Xu   +8 more
wiley   +1 more source

A SERS‐Based Antibody‐Aptamer Sandwich Assay for Extracellular Vesicle‐Associated Tau Detection Using Gold Nanoparticles

Advanced Sensor Research, Volume 4, Issue 8, August 2025.
Tau protein plays a critical role in the pathology of Alzheimer's disease, utilizing extracellular vesicles (EVs) as a mechanism for intercellular transmission. This study develops a highly sensitive sandwich assay biosensor for detecting and quantifying tau‐associated EVs using surface‐enhanced Raman spectroscopy (SERS).
Saqer Al Abdullah, Samaneh Ghadami, Md. Arifur Rahman Khan, Farbod Ebrahimi, Kyle Nowlin, Tetyana Ignatova, Kristen Dellinger   +6 more
wiley   +1 more source

Pyruvate Carboxylase in Macrophages Aggravates Atherosclerosis by Regulating Metabolism Reprogramming to Promote Inflammatory Responses Through the Hypoxia‐Inducible Factor‐1 Signaling Pathway

Advanced Science, Volume 12, Issue 29, August 7, 2025.
This study investigates the role of macrophage pyruvate carboxylase (PC) in atherosclerosis (AS) demonstrating that PC upregulation in macrophages promotes metabolism reprogramming to enhance inflammatory responses via the HIF‐1 signaling pathway.
Ling‐Na Zhao, Rui‐Ling Wang, Ran‐Xin Liu, Meng‐Ru Zheng, Li Zhao, Bao‐Feng Li, Jia‐Le Li, De‐Shen Liu, Xiao‐Xia He, Qin‐Bao Peng, Kai Li, Tian‐Xiao Lin, Ying‐Ying Liu, Sheng‐Ping He, Jun Lu, Shao‐Yi Zheng, Xiu Liu, Fang‐Ze Huang   +17 more
wiley   +1 more source

Atherosclerosis and plaque rupture: an update.

JPMA. The Journal of the Pakistan Medical Association, 1999
Afzal, M N, Saeed, S A, Shah, B H
openaire   +1 more source