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Visualization of the Spiral Ganglion Neuron in Vivo Using a Novel 177Lu Nuclear Molecule Label
Advanced Science, Volume 12, Issue 29, August 7, 2025.The study developed and validated a radionuclide‐labeled anti‐VGLUT1 antibody probe for the first nuclear imaging of cochlear spiral ganglion neurons (SGNs) in vivo. This approach may provide aid in screening candidates suitable for CI surgery by quantifying the number of surviving SGNs, and predicting the potential for postoperative hearing ...
Chenyang Kong +11 more
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Mouse models of plaque rupture
Current Opinion in Lipidology, 2013Atherosclerotic plaque destabilization and rupture is an important pathological condition that may account for approximately 70% of acute myocardial infarction cases. To analyse the mechanisms by which an atherosclerotic plaque destabilizes and ruptures and examine the effects of novel therapeutic approaches, several groups have developed mouse models ...
T. Matoba, Kei Sato, K. Egashira
semanticscholar +3 more sources
Plaque Rupture and Plaque Erosion
Thrombosis and Haemostasis, 1999SummaryThere are multiple substrates for coronary thrombosis overlying an atherosclerotic plaque. The most common, plaque rupture, consists of an interruption of a thin fibrous cap overlying a lipid rich core. Plaque rupture is a result of macrophage infiltration and matrix degradation, is often seen in calcified plaques, and is highly associated with ...
Renu Virmani +2 more
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HISTOPATHOLOGY OF PLAQUE RUPTURE
Cardiology Clinics, 1999Plaque disruption occurs during the development of atherosclerotic lesions. During certain circumstances it may result in thrombosis and subsequent development of acute coronary syndromes. Several characteristics of the plaque appear to be associated with plaque disruption, including a large lipid rich core, superficial plaque inflammation, and a thin ...
Ravn, Hanne Berg, Falk, Erling
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The Lancet, 2009
A 74-year-old man presented with left-sided monocular visual loss as a result of branch retinal artery occlusion. Carotid ultrasonography showed mild (20%) left carotid artery stenosis but no embolic source was identifi ed. MRI of the carotid artery showed a large atherosclerotic plaque at the origin of the left internal carotid artery, despite only ...
Raad H. Mohiaddin +4 more
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A 74-year-old man presented with left-sided monocular visual loss as a result of branch retinal artery occlusion. Carotid ultrasonography showed mild (20%) left carotid artery stenosis but no embolic source was identifi ed. MRI of the carotid artery showed a large atherosclerotic plaque at the origin of the left internal carotid artery, despite only ...
Raad H. Mohiaddin +4 more
openaire +3 more sources
2021
Despite improvement in the treatment, prevention, and risk factor management of atherosclerosis, the most frequent cause of death globally remains coronary artery disease. Therefore, it is essential to understand the underlying mechanisms involved in the manifestation of acute coronary syndromes, sudden cardiac death, or stable ischaemic heart disease.
Hiroyoshi Mori, Sho Torii, Renu Virmani
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Despite improvement in the treatment, prevention, and risk factor management of atherosclerosis, the most frequent cause of death globally remains coronary artery disease. Therefore, it is essential to understand the underlying mechanisms involved in the manifestation of acute coronary syndromes, sudden cardiac death, or stable ischaemic heart disease.
Hiroyoshi Mori, Sho Torii, Renu Virmani
openaire +1 more source
Drug Discovery Today: Disease Models, 2007
The most common underlying cause of the acute coronary syndromes is atherosclerotic plaque rupture, which is therefore of major clinical and pathological importance. Further insight into the aetiology of plaque rupture is essential to the development of new therapeutic strategies.
Sharada Karanam +3 more
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The most common underlying cause of the acute coronary syndromes is atherosclerotic plaque rupture, which is therefore of major clinical and pathological importance. Further insight into the aetiology of plaque rupture is essential to the development of new therapeutic strategies.
Sharada Karanam +3 more
openaire +2 more sources
Echolucent rupture-prone plaques
Current Opinion in Lipidology, 2003Routine measurement of echolucency of atherosclerotic plaques, in addition to degree of stenosis, may change clinical practice in the future. Within the context of previous knowledge in this field, we therefore review recent developments in detection and histological characterization of echolucent rupture-prone plaques and risk for ischaemic events ...
Henrik Sillesen +2 more
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PATHOPHYSIOLOGY OF PLAQUE RUPTURE AND THE CONCEPT OF PLAQUE STABILIZATION
Cardiology Clinics, 1996Atherosclerotic coronary artery disease is the major cause of death, in men and women, in the United States and in much of the Western world. Atherosclerosis is responsible for coronary heart disease, limb ischemia, and most strokes. Although luminal narrowing by an atherosclerotic plaque and exaggerated or anomalous vasoconstriction contribute to some
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2007
It is widely believed that rupture of a vulnerable atherosclerotic plaque leads to acute coronary events and stroke. However, the exact mechanisms involved in the plaque rupture remain unknown. Pathological animal models are valuable in the research on human disease mechanism, their therapy, and drug development.
Masafumi Kuzuya +2 more
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It is widely believed that rupture of a vulnerable atherosclerotic plaque leads to acute coronary events and stroke. However, the exact mechanisms involved in the plaque rupture remain unknown. Pathological animal models are valuable in the research on human disease mechanism, their therapy, and drug development.
Masafumi Kuzuya +2 more
openaire +3 more sources