TH17–Associated Polyamine Metabolism‐Guided Nanozyme Promotes Alveolar Bone Repair in Periodontitis
Advanced Science, EarlyView.A pronounced TH17‐skewed immune response is identified in experimental periodontitis, and enrichment of the polyamine pathway is observed during TH17 differentiation, suggesting its potential as an immunometabolic target. Inspired by these findings, DFMO@Ui‐Mn is developed as a therapeutic platform combining cascade ROS scavenging with immunometabolic ...
Cheng Zhu +12 more
wiley +1 more source
Integration of Transcriptional Signatures from Brain Tissue and Plasma Extracellular Vesicles of a Preclinical Tauopathy Mouse Model. [PDF]
Int J Mol SciLucy TT +5 more
europepmc +1 more source
Advanced Science, EarlyView.A yolk–shell PTFE‐based composite (YSP) enables tunable, robust hydrophobic–water interfaces for efficient, on‐demand sonocatalytic H2O2 generation and pollutant degradation. ABSTRACT The use of polytetrafluoroethylene (PTFE) particles to promote sonochemical H2O2 production has attracted growing interest, as cavitation bubbles formed at or near their ...
Rong Wang +6 more
wiley +1 more source
Multi-omics integration identifies a gut-microbiota-associated plasma metabolite signature for alzheimer disease diagnosis and metabolic pathway targeting. [PDF]
Front PharmacolChen J +5 more
europepmc +1 more source
Geomagnetic control of equatorial plasma bubble activity modeled by the TIEGCM with Kp
, 2014 Brett Carter +10 more
semanticscholar +1 more source
Monolayer MoS2 With Ultrahigh Piezoelectricity: From ALD Dose Control to Device Performance
Advanced Science, EarlyView.This study demonstrates that controlling precursor dosages in atomic layer deposition (ALD) serves to regulate ultrathin oxide quality, which in turn determines sulfurization behavior and MoS2 monolayer continuity. The resulting continuous, low‐defect monolayers enable improved piezoelectric performance and support a flexible slippage sensor, linking ...
Yun Li +16 more
wiley +1 more source
Amino acid- and lipid-related metabolic remodeling in PTZ-kindled mice reveals candidate plasma signatures of chronic epilepsy. [PDF]
Front NeurosciRen J, Wang F, Li Z, Liang Z, Liu S.
europepmc +1 more source
NICE: A Two‐Step Non‐Invasive Framework for Embryo cfDNA Read Enrichment and Quality Assessment
Advanced Science, EarlyView.The non‐invasive NICE framework, built on an ensemble stacking machine learning model, prioritizes embryos by analyzing cell‐free DNA from spent culture medium. By integrating multimodal signals, including genomic and epigenetic profiles, this automated approach standardizes morphological assessment without human bias, paving the way for more precise ...
Xueya Zhou +6 more
wiley +1 more source
Plasma miR-34a-5p outperforms miR-126-3p in predicting cognitive decline in cerebral small vessel disease patients with impaired glucose regulation. [PDF]
Front Aging NeurosciWang Y +5 more
europepmc +1 more source
Artificial Intelligence‐Empowered Single‐Cell Phenotyping for Rapid, Automated Pathogen Diagnostics
Advanced Science, EarlyView.This work presents an integrated diagnostic platform that combines microfluidic single‐cell bacterial detection with artificial intelligence‐driven analysis for rapid antimicrobial susceptibility testing. Single‐cell phenotyping enables assessment of antibiotic response in only a few cell replication cycles, while AI analysis supports precise bacterial
Sabita Khadka +3 more
wiley +1 more source