Results 131 to 140 of about 2,412,458 (308)
Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi +7 more
wiley +1 more source
Plasma Cell Infiltrate in Liver Allograft Biopsy: Clinical and Histological Implications
Introduction: The relevance of plasma cells in the allograft liver is of utmost importance and objective assessment of these infiltrates and correlation with other ancillary findings needs to be evaluated.
Neha Agrawal +4 more
doaj +1 more source
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida +6 more
wiley +1 more source
Auer Rod-Like Inclusions in Reactive Plasma Cells in a Case of Acute Myeloid Leukemia
Sarita Pradhan
doaj +1 more source
Inhibition of A2AR alleviates adenosine-mediated suppression of plasma cell differentiation
IntroductionHigh levels of extracellular adenosine, highly abundant in the tumor microenvironment, promote immune suppression mainly through the A2AR expressed by tumor-infiltrating immune cells.
Paola Tieppo +22 more
doaj +1 more source
Promiscuous stimulation of HSP70 ATPase activity by parasite‐derived J‐domains
The malaria parasite Plasmodium falciparum exports three highly homologous yet functionally divergent J‐domain proteins into human erythrocytes. Here, we show that J‐domains isolated from all three proteins effectively stimulate the ATPase activity of both endogenous host and exported parasite HSP70 chaperones.
Julian Barth +6 more
wiley +1 more source
EFFECT OF DIFFERENT ROUTES OF VACCINATION AGAINST NEW-CASTLE DISEASE ON LYMPHOID ORGANS OF BROILERS
This project was designed to compare two routes (intraocular and drinking water) of vaccination against Newcastle disease in ten11s of protection against velogenic field isolate of Newcastle disease virus (NOV), The immune response and morphological ...
R. Salam, A. Aslam. S. A, Khan, K. Saeed1 and G. Saleem
doaj
Immune checkpoint inhibitors (ICIs), particularly PD-1/PD-L1 antibodies, have significantly improved outcomes in a variety of solid tumors, including urothelial carcinoma.
Thilo Gambichler +5 more
doaj +1 more source
Erythropoietin administration suppresses hepatic soluble epoxide hydrolase (sEH) expression, leading to increased CYP‐derived epoxides. This is associated with a shift in hepatic macrophage polarization characterized by reduced M1 markers and increased M2 markers, along with reduced hepatic inflammation, suppressed hepatic lipogenesis, and attenuated ...
Takeshi Goda +12 more
wiley +1 more source

