Results 201 to 210 of about 2,412,458 (308)

Long‐Term Efficacy of Immunotherapy in Autoimmune Autonomic Ganglionopathy—A 10‐Year Follow Up Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Autoimmune autonomic ganglionopathy (AAG) is a rare but potentially treatable cause of severe autonomic failure. Evidence guiding long‐term immunotherapy, treatment sequencing, and residual autonomic impairment is limited. We evaluated long‐term treatment response, residual autonomic dysfunction, and relapse patterns in patients with
Giacomo Chiaro, Shiwen Koay, Gordon T. Ingle, Patricia McNamara, Laura Watson, Fion Bremner, Valeria Iodice   +6 more
wiley   +1 more source

Intratumoral plasma cells predict patient prognosis and responsiveness to neoadjuvant immunotherapy in advanced gastric cancer. [PDF]

NPJ Precis Oncol
Wang JB, Jiang CY, Ye YH, Gao YX, Zheng QL, Luo HY, Wang SH, Zhang T, Jin QW, Zheng CH, Li P, Lin JX, Chen QY, Cao LL, Yang YH, Huang CM, Xie JW.   +16 more
europepmc   +1 more source

MOGAD Is the Most Common Cause of Isolated Optic Neuritis in Children

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objectives The study aimed to characterize the clinical features, etiologies, and outcomes of isolated, first‐time pediatric ON in the post‐MOG‐IgG era. Methods This was a single‐center retrospective cohort study at Texas Children's Hospital of patients diagnosed with first‐time ON between 2018–2024, with follow‐up data collected through 2025.
Chaitanya Aduru, Akansha Chandrasekar, Kyla Blasingame, Jonathan Rosen, Jesse M. Levine, Karla Salazar, Madhuri Chilakapati, Rod Foroozan, Victoria Hardwick, Jonathan M. Yarimi, Nikita Shukla, Timothy E. Lotze, Kristen S. Fisher, Alexander J. Sandweiss   +13 more
wiley   +1 more source

PTEN restricts IL-21R signaling in GC B cells and suppresses their differentiation to plasma cells. [PDF]

J Immunol
Maldeney AR, Jiang W, Conter L, Wikenheiser DJ, Hawse WF, Patel A, Peng W, Shlomchik MJ, Luo W.   +8 more
europepmc   +1 more source

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Long-lived IgE plasma cells persist in secondary lymphoid tissues using a navitoclax-sensitive survival program. [PDF]

Immunity
Ding Z, Dowling MR, Wade-Vallance AK, Dvorscek AR, Pitt C, Mulder J, O'Donnell K, McKenzie C, Karaviotis AB, Scrofani J, Perdijk O, Hill DL, Quast I, Tarlinton DM, Allen CDC, Robinson MJ.   +15 more
europepmc   +1 more source

Peripheral Neutrophil Activation and Extracellular Trap Formation in Amyotrophic Lateral Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
Markers of neutrophil activation are increased in plasma during ALS, and markers of NET formation associate with ALS survival. ABSTRACT Objectives Peripheral neutrophil levels in amyotrophic lateral sclerosis (ALS) inversely correlate with survival, suggesting a role for neutrophils in disease progression.
Lillia A. Baird, Haley McQuown, Jihyun Park, Samuel J. Teener, Ian F. Webber‐Davis, Andrew D. Carter, Dae‐Gyu Jang, Eva L. Feldman, Stephen A. Goutman, Benjamin J. Murdock   +9 more
wiley   +1 more source

Dominant intragraft plasma cells targeting bilirubin implicate local heme catabolism in human cardiac allograft vasculopathy. [PDF]

J Clin Invest
See SB, Aguiar T, Dietzel M, Ausmeier M, Nguyen HT, Mashiko S, Donadeu L, Cordero H, Roy P, Roson L, Marboe CC, Szabolcs MJ, Farr M, González-Costello J, Olivella A, Naka Y, Takeda K, Vasilescu R, Clerkin KJ, Benichou G, Madsen JC, King RG, Bestard O, Kransdorf EP, Zorn E.   +24 more
europepmc   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Next-generation flow cytometry analysis of clonal bone marrow plasma cells identifies an indolent subset of MGUS. [PDF]

Blood Adv
Óskarsson JÞ, Thorsteinsdottir S, Rögnvaldsson S, Ólafsson A, Viðarsdóttir G, Guðmundsdóttir ER, Eythorsson E, Jónsson Á, Viðarsson B, Önundarson PT, Agnarsson BA, Sigurðardóttir M, Þorsteinsdóttir I, Ólafsson Í, Harding SJ, Durie BG, Love TJ, Kristinsson SY.   +17 more
europepmc   +1 more source