Results 91 to 100 of about 845,202 (292)

Elemental abundances of Galactic bulge planetary nebulae from optical recombination lines

, 2007
(abridged) Deep long-slit optical spectrophotometric observations are presented for 25 Galactic bulge planetary nebulae (GBPNe) and 6 Galactic disk planetary nebulae (GDPNe).
Aaquist, Acker, Acker, Acker, Alexander, Aller, Asplund, Bahcall, Barlow, Bastin, Cahn, Cardelli, Condon, Cuisinier, Davey, Dopita, Drake, Durand, Ercolano, Escudero, Escudero, Exter, Feldman, Fulbright, Fulbright, Garnett, Geisler, Grevesse, Górny, Henry, Henry, Howarth, Ibata, Iben, Idiart, Karakas, Karakas, Kingsburgh, Kisielius, Kisielius, Kwok, Köppen, Leisy, Lester, Liefke, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Liu, Lodders, Luo, Marigo, Massa, Mathis, McWilliam, McWilliam, Middlemass, Nakasato, Peimbert, Pottasch, Pottasch, Péquignot, Péquignot, Ratag, Ratag, Renzini, Rich, Ruffle, Schmelz, Seaton, Shen, Simpson, Simpson, Stanghellini, Stasińska, Storey, Tsamis, Tsamis, Tylenda, Tylenda, Udalski, Van Den Bergh, W. Wang, Walton, Wang, Webster, Wesson, Wesson, Wesson, Whitford, X.-W. Liu, Zhang, Zhang, Zhang, Zhang, Zhang, Zijlstra   +103 more
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Plasma biomarkers increase diagnostic confidence in patients with Alzheimer’s disease or frontotemporal lobar degeneration

Alzheimer’s Research & Therapy
Background The recent development of techniques to assess plasma biomarkers has changed the way the research community envisions the future of diagnosis and management of Alzheimer’s disease (AD) and other neurodegenerative disorders.
Daniele Altomare, Ilenia Libri, Antonella Alberici, Jasmine Rivolta, Alessandro Padovani, Nicholas J. Ashton, Henrik Zetterberg, Kaj Blennow, Barbara Borroni   +8 more
doaj   +1 more source

A Roadmap for Developing Plasma Diagnostic and Prognostic Biomarkers of Cerebral Cavernous Angioma With Symptomatic Hemorrhage (CASH). [PDF]

Neurosurgery, 2021
Girard R, Li Y, Stadnik A, Shenkar R, Hobson N, Romanos S, Srinath A, Moore T, Lightle R, Shkoukani A, Akers A, Carroll T, Christoforidis GA, Koenig JI, Lee C, Piedad K, Greenberg SM, Kim H, Flemming KD, Ji Y, Awad IA.   +20 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Random capillary blood glucose in the diagnosis of diabetes: a cross-sectional study in Bangladesh

BMJ Open
Objective To assess the effectiveness of random capillary blood glucose as a diagnostic tool for type 2 diabetes and determine optimal cut-off values for adults in Bangladesh.Design Cross-sectional diagnostic accuracy study.Setting 16 diabetes centres ...
Hajera Mahtab, Md Faruque Pathan, Md Robed Amin, Tasnima Siddiquee, Bishwajit Bhowmik, Sanjida Binte Munir, Shaila Parvin, Tareen Ahmed, Faria Afsana, Nazmul Kabir Qureshi, Ahmed Salam Mir, Rubayat Islam, Md Sarowar Uddin Milon, Rahat Iqbal Chowdhury, Rie Ozaki, Dulal Chandra Ray, Sumon Rahman Chowdhury, Sanjib Salah Aufi, Shamima Akhtar, Tamanna Afroz, Mohammad Abdus Samad, Abul Kalam Azad Khan   +21 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source