Results 81 to 90 of about 5,100,657 (294)

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Plasma Flow and Temperature in a Gliding Reactor with Different Electrode Configurations

Acta Polytechnica, 2012
This paper deals with the plasma flow shape depending on the electrode form of a gliding discharge plasma-chemical reactor, and with the temperature distribution along the direction of the plasma flow in one specific electrode form.
J. Sláma
doaj  

Carbon black on ordered scaffold of titania nanotubes as smart nanoengineered material for the next generation of highly sensitive electrode

Electrochemistry Communications
This study presents the first three-electrode system, which combines the extensive nanostructured surface of hydrogenated TiO₂ nanotubes and the electrochemical properties of carbon black to develop an electrochemical sensor with a nanoengineered surface.
Wiktoria Lipińska, Christian Gosti, Luca Fiore, Jakub Karczewski, Katarzyna Siuzdak, Fabiana Arduini   +5 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Heat transfer deterioration in helically coiled tubes with supercritical water: A numerical study on the impact of cross-sectional shapes

Case Studies in Thermal Engineering
Supercritical water flow in helically coiled tubes (HCTs) offers a promising solution for high-efficiency, compact heat exchangers in advanced power systems. This study conducts a numerical investigation of wall temperature and heat transfer coefficient (
Jiaqi Yang, Xiaoyi Wu, Haode Zheng, Zheng Lu, Shaopeng Si, Fucheng Chang, Huixiong Li   +6 more
doaj   +1 more source

The Effect of Gas Flow on Plasma Parameters Induced by Microwave

مجلة بغداد للعلوم, 2018
In this paper, construction microwaves induced plasma jet(MIPJ) system. This system was used to produce a non-thermal plasma jet at atmospheric pressure, at standard frequency of 2.45 GHz and microwave power of 800 W.
Baghdad Science Journal
doaj   +1 more source

Extracellular vesicle lipidomics liquid biopsy reveals systemic and tumor microenvironment metabolic reprogramming in ovarian cancer

Molecular Oncology, EarlyView.
Extracellular vesicle (EV) lipidomic profiling of plasma and ascites from patients with high‐grade serous ovarian cancer and of ovarian cancer cell lines reveals enrichment of triglycerides (TGs), diacylglycerols (DGs), phosphatidylcholine (PCs), sphingomyelins (SMs), reflecting tumor metabolic reprogramming.
Shikha Rani, Dominic Guanzon, Andrew Lai, Katherin Scholz‐Romero, Sarah Reed, Edita Ritmejeryte, Rohan Lourie, Naven Chetty, Kaltin Ferguson, Carlos Salomon   +9 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Three dimensional simulation of the arc inside an insulator-arrester with a multichamber system

AIP Advances, 2016
Based on the thermo-physical properties of plasma air, the temperature and flow fields of an insulator–arrester with a multi-chamber system are investigated using three-dimensional computational fluid dynamics.
Zhiwei Guo, Xinping Long, Zhongdong Qian, Ning Qiu   +3 more
doaj   +1 more source

Three Flow Features behind the Flow Control Authority of DBD Plasma Actuator: Result of High-Fidelity Simulations and the Related Experiments

Applied Sciences, 2018
Both computational and experimental studies are conducted for understanding of the flow separation control mechanism of a DBD (dielectric barrier discharge) plasma actuator. Low speed flows over an airfoil are considered.
Kozo Fujii
doaj   +1 more source